A0A1S5YCF7 · A0A1S5YCF7_9CALI

  • Protein
    Genome polyprotein
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    3/5

Function

function

Displays NTPase activity, but no helicase activity. Induces the formation of convoluted membranes derived from the host ER. These remodeled membranes probably form the viral factories that contain the replication complex. Together with NS2 and NS4, initiates the formation of the replication complex.
Probable key protein responsible for the formation of membrane alterations by the virus. Induces the formation of convoluted membranes derived from the host ER. These remodeled membranes probably form the viral factories that contain the replication complex. Together with NS2 and NTPase, initiates the formation of the replication complex.
Together with NTPase and NS4, initiates the formation of the replication complex. Induces the proliferation of the host smooth ER membranes forming long tubular structures. These remodeled membranes probably form the viral factories that contain the replication complex.
Viral genome-linked protein is covalently linked to the 5'-end of the positive-strand, negative-strand genomic RNAs and subgenomic RNA. Acts as a genome-linked replication primer. May recruit ribosome to viral RNA thereby promoting viral proteins translation. Interacts with host translation initiation complex to allow the translation of viral proteins.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componenthost cell cytoplasm
Cellular Componentmembrane
Cellular Componentvirion component
Molecular FunctionATP binding
Molecular Functioncysteine-type endopeptidase activity
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionRNA binding
Molecular FunctionRNA helicase activity
Molecular FunctionRNA-dependent RNA polymerase activity
Biological ProcessDNA-templated transcription
Biological Processproteolysis
Biological ProcessRNA-protein covalent cross-linking
Biological Processviral RNA genome replication

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Genome polyprotein

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bat-SaV/Lysoka36/CAM/2014
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Caliciviridae > Sapovirus

Accessions

  • Primary accession
    A0A1S5YCF7

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane40-58Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain167-322SF3 helicase
Domain773-920Peptidase C24
Region935-973Disordered
Domain1162-1287RdRp catalytic
Region1438-1467Disordered
Compositional bias1450-1467Polar residues

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    1,911
  • Mass (Da)
    209,288
  • Last updated
    2017-05-10 v1
  • MD5 Checksum
    8ADD62C6D530F5B6F137C3CDC91256A4
KAGMSCVGLATRLFEYLYDFSKDLWRTFKSWWAGLFQPESGNTMILVVGVVGFIYFLATQTVPGKFLTKHLLKIAGMLTGGAAAFKSVEYIINYLKTSHHNSCVQQFMARHAALIEVIDAQNEAGTLEAEGLIKCCDIIASEGTTLISENPTSATSGLLRTLVATVEERKSRLTQTVKMDLPRPVPQMFIFGGPPGIGKTRLVQHIAKLLDERTSTFSLAVDHHDAYTGNPIAIWDEFDVDKDGKFVEMVVSIVNSSPCPLNCDRPENKGKMFTSKYILATTNCPTPVVPEHPRANAFWRRVNFVDVCSPDIESFMKRNPGRTIPKNLYKNDFSHLELXLRPYLGVTPDGVLIDGRRAAGARITPDDVVALMKKNFEAQARTPHVLWLKMPTKMLTQAHKLVKGWAYYSGSLVQVVTTLTAEQAMNPSGPGFIVISDQDAPVGNIFEMLVYDFSDNAARVGPELPCDSINDLFKVQNSRVPGHILRHIMYHIHGHHTHLHDIQLNIAEIPRPKNMVIVSTPLELIKPLWRHLSVSSIPGYRTLVKGGLKGANYFDLMVATVSQLKFGPNPECTLFRTPGGDIILYTCGGSFVFGTPARYPLVAPVDYPTFRHKHGRDTTWFDLFLSSLEILAKGILPYVPLIISMVNVSYLVHRQHRGVEAKGKTKRGRGRIHALQDDEYEEYRDVKRDWRQEMTVSEFLEIRQKAFAGSMDPTSQRYRAWLELRELRASNNAYRYDINTVIGKKGVRDQIQRLDLIKAPKERDIYDGYESQAPSHLLEFTDGEHHVGWGIHVGGGKVVTCTHVCDMATEVEGLPFSKLETVSDITFVKTEYSGPFKQIGSGEPNYFQDQCHVVRVLESGTFDTPTTSVSGWTIKILNNTPTKKGDCGLPYYDANHRLVGLHSGASLQGSVKLVSRVPQSNTPIKDRFSWKGLMVSRGPNTGGMPTGTRYHRSPAFPTPLPDETHSPAPFGIGDPRYSHTQVEMLVNGLKPYQQTPVLAFDRVLLQRALHHTRATLRGLIGTHLSRNLTFTESCLALERSTSCGPFVPGIKSDYWDERDTNIFRSVAPTFGSILGYGTSWPSPPKCIQIGFEGNELRPNEKNAEGKRRLLWGADAGVTLICTAALKNVSERLAEVVPVNPIAVGTNMDSPQVEMMNAALVNRVVYNVDYSKWDSTMQPTIISAAVNLLSEWCEPSQITSAATQILTSRAIGHFEDVVFQANTGLPSGMPFTSVINSTCHMILLAMAILKAYEDVGVPYTGVVFENEVVWTYGDDGLYGFTLATSSLMPKILDNLRSFGLSPTAPDKSPEITPTLSPVFLKRTFITTPNGVRAALDQSSILRQFYWVKAQRTSDINSPPRFDPLVRTQQLTVALAMSAVHGPDFYQKVSEIARKCADAEGLVLICDYNESITMYEAWYHGKSPIVESVPTEVPDKLVFEMEGPGPQSALPEGAANDSTAPTVPTGGVTTDPVVQAVQMAAATGSLNLSLPPEVTSTFAVLGNLTWTNRQSPGALIGSYRLGPQVNPYLAHLSAMWGAWGGGTEFRITVSGSGLFAGKLMIAIVPPGVDPTKMPTPGALPHALLDARTTDPVVFALPDVRATAYHIVGQLTDVPTIGLWVFNALINPFSSAEALAACTVTIETRPQADFTFGMLLPPNTADSASSNPSHLLPRRLGFSRGNRTGGLIRGAQIVATANQVNHHWNASGRTFGWSVGPPDFVSVQTYDSSTTPTYRTVFGISTPIISKVANHWPDYSVSYPVNGVQSLDMSSNSGLKPGANWKGVACLAAMMDGNTGDVDTDSSRMVLPATGSVVSGAFRPAVTLSDNQMLFLLNRNESSFTGGVVVFTPISTNGSNTVITERCLTLPTGGRTVGPLGPNTQCCGRKRSVVILVGLLIVWHHSSSQLLTSFLKAL

Features

Showing features for non-terminal residue, compositional bias.

Type
IDPosition(s)Description
Non-terminal residue1
Compositional bias1450-1467Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KX759619
EMBL· GenBank· DDBJ
AQQ78875.1
EMBL· GenBank· DDBJ
Genomic RNA

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