A0A1S4GYH9 · D7R3_ANOGA

Function

function

Modulates blood feeding of female mosquitoes on vertebrate species by binding and sequestering different mediators involved in the host response (By similarity).
Binds serotonin, noradrenaline, histamine and adrenaline (PubMed:16301315).
Inhibits histamine-, serotonin- and noradrenaline-induced smooth muscle contraction (PubMed:16301315).
Exhibits vasodilating activity (PubMed:16301315).

Features

Showing features for binding site.

116920406080100120140160
TypeIDPosition(s)Description
Binding site31noradrenaline (UniProtKB | ChEBI)
Binding site31serotonin (UniProtKB | ChEBI)
Binding site46noradrenaline (UniProtKB | ChEBI)
Binding site59serotonin (UniProtKB | ChEBI)
Binding site118histamine (UniProtKB | ChEBI)
Binding site118serotonin (UniProtKB | ChEBI)
Binding site135histamine (UniProtKB | ChEBI)
Binding site135noradrenaline (UniProtKB | ChEBI)
Binding site135serotonin (UniProtKB | ChEBI)
Binding site138histamine (UniProtKB | ChEBI)
Binding site138noradrenaline (UniProtKB | ChEBI)
Binding site138serotonin (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functionodorant binding
Biological Processvasodilation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Short form salivary protein D7R3
  • Alternative names
    • D7-related 3 protein

Gene names

    • Name
      D7r3

Organism names

  • Taxonomic identifier
  • Strains
    • Gasua
    • PEST
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Anophelinae > Anopheles

Accessions

  • Primary accession
    A0A1S4GYH9
  • Secondary accessions
    • O76816
    • Q9UB32

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_501014887522-169Short form salivary protein D7R3
Disulfide bond30↔62
Disulfide bond43↔168
Disulfide bond101↔120

Keywords

Expression

Tissue specificity

Female salivary gland (PubMed:9990055).
Low-level expression in female carcass without salivary glands (PubMed:9990055).
Not detected in male tissues (PubMed:11841502, PubMed:9990055).

Developmental stage

Not detected in embryo, larval and pupal stages.

Family & Domains

Sequence similarities

Belongs to the PBP/GOBP family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    169
  • Mass (Da)
    18,636
  • Last updated
    2017-04-12 v1
  • Checksum
    405024C44F8924E1
MFGKLLPCAILVWCLFSLGQARQEETVEECERNIPASLKGRVCELRQYTPVQGKDMDSHMQCVLEVLGFVEDNGELVFQELLGVLKMVDPDGDHASSMKKCNAEAEKVDTSSKANTFYTCFLGTSSAQAFKYAVDYVELLRAGKLDMGTTFNAGQVSALMKQIDDGLCN

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict12in Ref. 1; AAK84943/CAB39729 and 3; CAA03871
Sequence conflict40in Ref. 1; AAK84943/CAB39729 and 3; CAA03871
Sequence conflict96in Ref. 1; AAK84943/CAB39729 and 3; CAA03871
Sequence conflict103in Ref. 3; CAA03871

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ133854
EMBL· GenBank· DDBJ
CAB39729.1
EMBL· GenBank· DDBJ
mRNA
AY045760
EMBL· GenBank· DDBJ
AAK84943.1
EMBL· GenBank· DDBJ
Genomic DNA
AAAB01008964
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AJ000035
EMBL· GenBank· DDBJ
CAA03871.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp