A0A1S4F0I0 · AGBR1_AEDAE

Function

function

Promotes recruitment of host neutrophils at the bite site (PubMed:30858571).
Induces expression of IL1B and IL6 in the skin of the host (PubMed:30858571).
(Microbial infection) Enhances Zika virus replication and exacerbates disease pathogenesis in the host.

Miscellaneous

Immunization against the protein decreases early inflammatory responses in the skin of mice bitten by mosquitoes infected with Zika virus and partially protects susceptible mice from lethal Zika virus infection.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functionchitin binding
Molecular Functionchitinase activity
Biological Processcarbohydrate metabolic process
Biological Processchitin catabolic process

Names & Taxonomy

Protein names

  • Recommended name
    Bacteria-responsive protein 1
  • Short names
    AgBR1

Organism names

  • Taxonomic identifier
  • Strain
    • LVP_AGWG
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Culicinae > Aedini > Aedes > Stegomyia

Accessions

  • Primary accession
    A0A1S4F0I0

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown reduces neutrophil recruitment in the host skin after mosquito bite.

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

Type
IDPosition(s)Description
Signal1-18
ChainPRO_000046106619-441Bacteria-responsive protein 1
Glycosylation20N-linked (GlcNAc...) asparagine
Disulfide bond29↔56
Glycosylation225N-linked (GlcNAc...) asparagine

Keywords

Expression

Tissue specificity

Salivary gland (at protein level).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain25-441GH18

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    441
  • Mass (Da)
    48,682
  • Last updated
    2018-02-28 v1
  • Checksum
    4E7227E9DDFCC54F
MWFFKVGALLFLAALVSANNATTGPKVLCYYDGQMSLREGLGKITVTDIELALPFCTHLLYGFAGVNPETYRLKALDESLELDSGKGQYRLATTLKRRYPNLKVLLSVGGYKDLAEEKPFEKYLTLLESAGSRTAFVNSVYSTLKTYDFDGLDLAWQFPQTKPKRIRGWTGKVWHGFKKLFTGDSVLDPKADEHREEFTALVRDLKNALVADNFILGLTVLPHVNESIFMDVPLLKDNLDYVNLASFDQQTPERNPKEGDYTAPIYEPSERVEGNNVDAEASYWLKQGTPAGKIVIGIPTYGRGWKLVEKSGITGVPPIPADGPSIPGPHSGINGFYSWAEVCAKLPNPGNANLQGADQPLRKIGDPTRRFGAYAFRIPDENEEHGIWLSYEDPDTAGNKAAYVKAKGLGGISIFDLGNDDVRGACAGDKFPILRAAKYRL

Keywords

Genome annotation databases

Similar Proteins

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