A0A1S4DF18 · QPT1B_TOBAC
- ProteinQuinolinate phosphoribosyltransferase [decarboxylating] 1b
- GeneQPT1b
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids350 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins); nornicotine serves as the precursor in the synthesis of the carcinogen compound N'-nitrosonornicotine (NNN) (Probable) (PubMed:31276744).
Involved in the catabolism of quinolinic acid (QA) (Probable)
Involved in the catabolism of quinolinic acid (QA) (Probable)
Catalytic activity
- CO2 + diphosphate + nicotinate beta-D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H+ + quinolinateThis reaction proceeds in the backward direction.
Pathway
Alkaloid biosynthesis; nicotine biosynthesis.
Cofactor biosynthesis; NAD+ biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 141 | substrate | ||||
Sequence: R | ||||||
Binding site | 172-174 | substrate | ||||
Sequence: TRK | ||||||
Binding site | 196 | substrate | ||||
Sequence: R | ||||||
Binding site | 206 | substrate | ||||
Sequence: K | ||||||
Binding site | 239 | substrate | ||||
Sequence: E | ||||||
Binding site | 266 | substrate | ||||
Sequence: D | ||||||
Binding site | 298-300 | substrate | ||||
Sequence: SGN | ||||||
Binding site | 319-321 | substrate | ||||
Sequence: SGA |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | nicotinate-nucleotide diphosphorylase (carboxylating) activity | |
Biological Process | alkaloid metabolic process | |
Biological Process | NAD biosynthetic process | |
Biological Process | nicotine biosynthetic process | |
Biological Process | quinolinate catabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameQuinolinate phosphoribosyltransferase [decarboxylating] 1b
- EC number
- Short namesNtQPT1b
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > lamiids > Solanales > Solanaceae > Nicotianoideae > Nicotianeae > Nicotiana
Accessions
- Primary accessionA0A1S4DF18
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000455794 | 1-350 | Quinolinate phosphoribosyltransferase [decarboxylating] 1b | |||
Sequence: MFKVLPFTAIVHPNAITAPRLVVKMSAIATKNAVESFVVKPPAHPTYDLKGVIQLALSEDAGDIGDVTCKATIPIDMESEAHFLAKEDGIVAGIALAEMIFAEVDPSLKMEWSINDGDKVHKGLKFGKVQGKAHSIVIAERVVLNFMQRMSGIATLTKAMADAAHPATILETRKTAPGLRLVDKWAVLIGGGKNHRMGLFDMVMIKDNHISAAGGVSKALNSVDQYLEQNKLQMGVEVETRTIAEVHEVLEYASQTKTSLTRIMLDNMVVPLSNGDIEVSMLEEAVDLINGRFETEASGNVTLETVHKIGQTGVTYISSGALTHSVKALDISLKIDTELALEVGRRTKRA |
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
A0A1S4DF18-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length350
- Mass (Da)37,819
- Last updated2017-04-12 v1
- Checksum98EB6816B54AB3F9
A0A1S4DF18-2
- Name2
- Differences from canonical
- 1-24: Missing
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_061528 | 1-24 | in isoform 2 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term