A0A1S4CF55 · A0A1S4CF55_TOBAC

Function

function

Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.

Catalytic activity

  • Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.
    EC:3.1.4.1 (UniProtKB | ENZYME | Rhea)

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular Functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Molecular Functionphosphodiesterase I activity
Molecular Functionzinc ion binding
Biological Processinterstrand cross-link repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Fanconi-associated nuclease
  • EC number

Gene names

    • Name
      LOC107818303

Organism names

  • Taxonomic identifier
  • Strain
    • cv. TN90
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > lamiids > Solanales > Solanaceae > Nicotianoideae > Nicotianeae > Nicotiana

Accessions

  • Primary accession
    A0A1S4CF55

Proteomes

Subcellular Location

Keywords

  • Cellular component

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain56-85UBZ4-type
Region116-136Disordered

Sequence similarities

Belongs to the FAN1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    962
  • Mass (Da)
    109,048
  • Last updated
    2017-04-12 v1
  • Checksum
    50553A704BD2CF22
MLKGRESLIRLVGRRRRFLRRRHSLLTSSAPQHQIGCKEYKDEVSTGNGNVDEEEWVDCPVCGKKIRGEDRVVNSHLDKCLARGSKRKLSQCTLFQLNFCTRPKVTVSSIESDVTRIDVGPSTDDDGPENDIQEESKSSVCNRVNRMENLDGLIKLDDERKLLPDAKTMQIFGLEGSPQHQISEDRIDNIADSPLSLSEKRMPKCVEPSEDDDNSEILLDTFIVGRRFSNDGELTVGAMIMLARDPENVRDQNAIKVLTKDTDHNKELGYIPRELAQYLSPLIDKFHLRFEGHITSIPQHPHAVVPIQIYSSGIVSFGEKDSSSLQVFNSLRRNALSAAEFSKTHSPIPAKYQHNLLLLLKEVLNINGHLFTEGEKTLLEAFLSLSDDSQRLFARLYARKGPWFRMASISYAEICDYEEAVKGLSEAECVTLIESMNILQINDLKEVLNVLNVGELRDLISSLNKTHKKIAQNSDRGTRKQDYITRVLAAYQGGLCPNLTNMILGKTGRCIRISASAESVFWRAERLFFLNGEQDLSEFLLVDLGIVKYPAYNCIFTDQIFPDRSDLLSYEEAIEVAQIMDESLDENNNELVSRCIEISASNVSSFVEKDRSAHSGSMAAFLSRFSASWVYSKVILLGVSFLEHEQRYKEAINLLKLLLEKCKCDRRRGYWNLRLSIDLEHVGCLDESLEVAEKGLLDPWVRAGSRVALQRRVLRLGKPPRRWKTPSFSSSVKRKIVEVHVQGRPLNCKTGVKNVFYGEDGDRCGVEELALQYYAGEGGSWQGVHTESGIWLTMFGLLMWDVVFADVPNVFRTKFQTAPLDLETDSFYEVRRSRIEALLDKIEHGMAEELLIMSWESHVGIACRGVNWDKHSLSELRAAVTCIGGPCLASICRNLAQDYRSWSSGMPDLLLWRFRDDYRGEAKLVEVKGPRDRLSEQQRAWLLFLMDCGFNVEVCKVSHAPI

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1S4CF83A0A1S4CF83_TOBACLOC107818303987
A0A1S4CF32A0A1S4CF32_TOBACLOC107818303816
A0A1S4CF18A0A1S4CF18_TOBACLOC107818303986

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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