A0A1S3PLW3 · A0A1S3PLW3_SALSA
- ProteinSodium channel protein
- GeneLOC106586196
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1988 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | voltage-gated sodium channel complex | |
Molecular Function | voltage-gated sodium channel activity | |
Biological Process | membrane depolarization during action potential | |
Biological Process | neuronal action potential |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameSodium channel protein
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Salmoniformes > Salmonidae > Salmoninae > Salmo
Accessions
- Primary accessionA0A1S3PLW3
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 123-146 | Helical | ||||
Sequence: VLVHSLFSMVIMLTILTNCAFMTL | ||||||
Transmembrane | 191-210 | Helical | ||||
Sequence: WLDFCVIVMAYVTEFVDLGN | ||||||
Transmembrane | 222-243 | Helical | ||||
Sequence: ALKTISVIPGLKTIVGALIQSV | ||||||
Transmembrane | 249-269 | Helical | ||||
Sequence: VMILTVFCLSVFALVGLQLFM | ||||||
Transmembrane | 391-418 | Helical | ||||
Sequence: YMIFFVLVIFLGSFYLINLILAVVAMAY | ||||||
Transmembrane | 741-759 | Helical | ||||
Sequence: FVDLTITICIVLNTVFMAM | ||||||
Transmembrane | 771-794 | Helical | ||||
Sequence: MLSVGNLVFTGIFTAEMCFKIIAL | ||||||
Transmembrane | 806-830 | Helical | ||||
Sequence: IFDGIIVSLSLMEIGLANVSGMSVL | ||||||
Transmembrane | 851-879 | Helical | ||||
Sequence: LIKIIGNSVGALGNLTLVLAIIVFIFAVV | ||||||
Transmembrane | 941-964 | Helical | ||||
Sequence: LIVFMMVMVIGNLVVLNLFLALLL | ||||||
Transmembrane | 1194-1212 | Helical | ||||
Sequence: WFESFIIFMILLSSGALAF | ||||||
Transmembrane | 1233-1252 | Helical | ||||
Sequence: IFTYIFILEMLLKWVAYGFA | ||||||
Transmembrane | 1264-1284 | Helical | ||||
Sequence: FLIVDVSLVSLVANALGYAEL | ||||||
Transmembrane | 1310-1336 | Helical | ||||
Sequence: VVINALLGAIPSIFNVLLVCLIFWLIF | ||||||
Transmembrane | 1428-1454 | Helical | ||||
Sequence: LYMYLYFVVFIIFGSFFTLNLFIGVII | ||||||
Transmembrane | 1513-1531 | Helical | ||||
Sequence: AFDIVIMILICLNMVTMMV | ||||||
Transmembrane | 1543-1561 | Helical | ||||
Sequence: ILYKINLVFIVMFTGECIL | ||||||
Transmembrane | 1573-1593 | Helical | ||||
Sequence: IGWNVFDFIVVILSIIGMFLS | ||||||
Transmembrane | 1630-1658 | Helical | ||||
Sequence: LLFALMMSLPALFNIGLLLFLVMFIYAIF | ||||||
Transmembrane | 1733-1758 | Helical | ||||
Sequence: VAIIFFVSYIIICFLVVVNMYIAVIL |
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, domain, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 28-52 | Disordered | ||||
Sequence: IADENAKKSKAKPNNNDDDGPKPSS | ||||||
Domain | 126-424 | Ion transport | ||||
Sequence: HSLFSMVIMLTILTNCAFMTLSQPPDWAKNVEYTFTGIYTFESLIKILARGFCVGKFTFLRDPWNWLDFCVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRNKCLRIPLNSTDLFDDSFDFNGTDLNKTKSFNWTYYMNDPKNYYYLPGKKDALLCGNGSGAGLCPEGFWCIKAGRNPDYGYTSFDTFSWAFLSLFRLMTQDYWENLYQQTLRAAGKPYMIFFVLVIFLGSFYLINLILAVVAMAYDEQNQA | ||||||
Coiled coil | 415-449 | |||||
Sequence: AMAYDEQNQATIEEAQQKEEEFQKLKKQQEDAQAA | ||||||
Region | 451-513 | Disordered | ||||
Sequence: AVTAAESGEFSERGELTDTSSEASKLSSKSAKERRNRRKKKKQREEEERGDNDKFHRSESEGS | ||||||
Compositional bias | 490-513 | Basic and acidic residues | ||||
Sequence: KKKQREEEERGDNDKFHRSESEGS | ||||||
Domain | 541-690 | Voltage-gated Na+ ion channel cytoplasmic | ||||
Sequence: SFLSIRGPLFSSRRNSQASLFSFRDRAQDMGSENDFADDENSTFEDNESRRGSLFVPRRSDRRSSNLSQNSMSSHVLLPANGKKHSSVDCNGVVSLVGGASLPTSPEGLLLPEGNTTETEYRKARCESYQASMNFLEDPGARQRAFSVAS | ||||||
Region | 571-614 | Disordered | ||||
Sequence: GSENDFADDENSTFEDNESRRGSLFVPRRSDRRSSNLSQNSMSS | ||||||
Compositional bias | 583-598 | Basic and acidic residues | ||||
Sequence: TFEDNESRRGSLFVPR | ||||||
Compositional bias | 599-614 | Polar residues | ||||
Sequence: RSDRRSSNLSQNSMSS | ||||||
Domain | 740-970 | Ion transport | ||||
Sequence: PFVDLTITICIVLNTVFMAMEHHPMSGDFKKMLSVGNLVFTGIFTAEMCFKIIALDPYCYFKEGWNIFDGIIVSLSLMEIGLANVSGMSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYRDCVCKISTDCTLPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQSMCLIVFMMVMVIGNLVVLNLFLALLLSSFSAD | ||||||
Domain | 978-1188 | Sodium ion transport-associated | ||||
Sequence: DSEMNNLTVAIGRIHQGIAFVKALVCRSFHSICLRKKKGSLDDLHRTNYNSNHTTVEIMKDPEYVKDDNGTTGGVGMGVGSNAAGKYIVNDNTDYMQFIHNPSLTVTVPIAVGESDFENLNTEDFSSYSSDIEGSKEQLAKDRPLSSSEGSTVDIRAPGEREGSVDMEPEESMEAEGCFTDGCVRRFQCCQVNVEEGKWKMWWTLRKTCFR | ||||||
Region | 1113-1147 | Disordered | ||||
Sequence: KEQLAKDRPLSSSEGSTVDIRAPGEREGSVDMEPE | ||||||
Domain | 1192-1463 | Ion transport | ||||
Sequence: HNWFESFIIFMILLSSGALAFEDIYIEQRKTIKTLLEFADKIFTYIFILEMLLKWVAYGFAKYFTNAWCWLDFLIVDVSLVSLVANALGYAELSAIKSLRTLRALRPLRALSRFEGMRVVINALLGAIPSIFNVLLVCLIFWLIFSIMGVNLFAGKYYHCINMTTSDRFEVRDVANKTECLALTGTHWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRNLDDQPDYEVNLYMYLYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKK | ||||||
Domain | 1512-1768 | Ion transport | ||||
Sequence: QAFDIVIMILICLNMVTMMVETEDQTDDIRKILYKINLVFIVMFTGECILKMISLRQYYFTIGWNVFDFIVVILSIIGMFLSELIEKYLVSPTLFRVIRLARIGRILRLIKSAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKESGIDDMFNFETFGNSMICLFQITTSGGWDLLLAPILNKGEPDCDSRKEHPGSTYKGGDCGNPPVAIIFFVSYIIICFLVVVNMYIAVILENFSVATEES | ||||||
Compositional bias | 1941-1959 | Polar residues | ||||
Sequence: SDRTDMTPSTASPPSYDSV | ||||||
Region | 1941-1988 | Disordered | ||||
Sequence: SDRTDMTPSTASPPSYDSVTKPEKNKYKKDKRKKEVKEKKKYMDVGKI |
Sequence similarities
Belongs to the sodium channel (TC 1.A.1.10) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,988
- Mass (Da)225,951
- Last updated2017-04-12 v1
- Checksum3514921CB70F6F9D
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1S3PLV2 | A0A1S3PLV2_SALSA | LOC106586196 | 1999 | ||
A0A1S3PLZ5 | A0A1S3PLZ5_SALSA | LOC106586196 | 1875 | ||
A0A1S3PM38 | A0A1S3PM38_SALSA | LOC106586196 | 1988 | ||
A0A1S3PMY2 | A0A1S3PMY2_SALSA | LOC106586196 | 1999 | ||
A0A1S3PMZ4 | A0A1S3PMZ4_SALSA | LOC106586196 | 1750 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 490-513 | Basic and acidic residues | ||||
Sequence: KKKQREEEERGDNDKFHRSESEGS | ||||||
Compositional bias | 583-598 | Basic and acidic residues | ||||
Sequence: TFEDNESRRGSLFVPR | ||||||
Compositional bias | 599-614 | Polar residues | ||||
Sequence: RSDRRSSNLSQNSMSS | ||||||
Compositional bias | 1941-1959 | Polar residues | ||||
Sequence: SDRTDMTPSTASPPSYDSV |
Keywords
- Technical term