A0A1S3PLW3 · A0A1S3PLW3_SALSA

Function

function

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentaxon
Cellular Componentvoltage-gated sodium channel complex
Molecular Functionvoltage-gated sodium channel activity
Biological Processmembrane depolarization during action potential
Biological Processneuronal action potential

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Sodium channel protein

Gene names

    • Name
      LOC106586196

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Salmoniformes > Salmonidae > Salmoninae > Salmo

Accessions

  • Primary accession
    A0A1S3PLW3

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane123-146Helical
Transmembrane191-210Helical
Transmembrane222-243Helical
Transmembrane249-269Helical
Transmembrane391-418Helical
Transmembrane741-759Helical
Transmembrane771-794Helical
Transmembrane806-830Helical
Transmembrane851-879Helical
Transmembrane941-964Helical
Transmembrane1194-1212Helical
Transmembrane1233-1252Helical
Transmembrane1264-1284Helical
Transmembrane1310-1336Helical
Transmembrane1428-1454Helical
Transmembrane1513-1531Helical
Transmembrane1543-1561Helical
Transmembrane1573-1593Helical
Transmembrane1630-1658Helical
Transmembrane1733-1758Helical

Keywords

PTM/Processing

Keywords

Family & Domains

Features

Showing features for region, domain, coiled coil, compositional bias.

TypeIDPosition(s)Description
Region28-52Disordered
Domain126-424Ion transport
Coiled coil415-449
Region451-513Disordered
Compositional bias490-513Basic and acidic residues
Domain541-690Voltage-gated Na+ ion channel cytoplasmic
Region571-614Disordered
Compositional bias583-598Basic and acidic residues
Compositional bias599-614Polar residues
Domain740-970Ion transport
Domain978-1188Sodium ion transport-associated
Region1113-1147Disordered
Domain1192-1463Ion transport
Domain1512-1768Ion transport
Compositional bias1941-1959Polar residues
Region1941-1988Disordered

Sequence similarities

Belongs to the sodium channel (TC 1.A.1.10) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,988
  • Mass (Da)
    225,951
  • Last updated
    2017-04-12 v1
  • Checksum
    3514921CB70F6F9D
MAQLLVPPGPDSFRPFCRESLDAIERRIADENAKKSKAKPNNNDDDGPKPSSDLEAGKSLPLIYGDIPKGLVSTPLEDLDTFYSNQKTFIVLNRGKAIFRFNATPALYVLNPFNPLRRISIKVLVHSLFSMVIMLTILTNCAFMTLSQPPDWAKNVEYTFTGIYTFESLIKILARGFCVGKFTFLRDPWNWLDFCVIVMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRNKCLRIPLNSTDLFDDSFDFNGTDLNKTKSFNWTYYMNDPKNYYYLPGKKDALLCGNGSGAGLCPEGFWCIKAGRNPDYGYTSFDTFSWAFLSLFRLMTQDYWENLYQQTLRAAGKPYMIFFVLVIFLGSFYLINLILAVVAMAYDEQNQATIEEAQQKEEEFQKLKKQQEDAQAAAAVTAAESGEFSERGELTDTSSEASKLSSKSAKERRNRRKKKKQREEEERGDNDKFHRSESEGSVQKSRFRFSIDASNLLNYDMRCSTPHQSFLSIRGPLFSSRRNSQASLFSFRDRAQDMGSENDFADDENSTFEDNESRRGSLFVPRRSDRRSSNLSQNSMSSHVLLPANGKKHSSVDCNGVVSLVGGASLPTSPEGLLLPEGNTTETEYRKARCESYQASMNFLEDPGARQRAFSVASVITNTMEELEESRQECPPCWYKFSNTFLIWDCCPAWLRIKKTVKMIVMDPFVDLTITICIVLNTVFMAMEHHPMSGDFKKMLSVGNLVFTGIFTAEMCFKIIALDPYCYFKEGWNIFDGIIVSLSLMEIGLANVSGMSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYRDCVCKISTDCTLPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAGQSMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDSEMNNLTVAIGRIHQGIAFVKALVCRSFHSICLRKKKGSLDDLHRTNYNSNHTTVEIMKDPEYVKDDNGTTGGVGMGVGSNAAGKYIVNDNTDYMQFIHNPSLTVTVPIAVGESDFENLNTEDFSSYSSDIEGSKEQLAKDRPLSSSEGSTVDIRAPGEREGSVDMEPEESMEAEGCFTDGCVRRFQCCQVNVEEGKWKMWWTLRKTCFRIVEHNWFESFIIFMILLSSGALAFEDIYIEQRKTIKTLLEFADKIFTYIFILEMLLKWVAYGFAKYFTNAWCWLDFLIVDVSLVSLVANALGYAELSAIKSLRTLRALRPLRALSRFEGMRVVINALLGAIPSIFNVLLVCLIFWLIFSIMGVNLFAGKYYHCINMTTSDRFEVRDVANKTECLALTGTHWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRNLDDQPDYEVNLYMYLYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPVNKFQGFVFDFITKQAFDIVIMILICLNMVTMMVETEDQTDDIRKILYKINLVFIVMFTGECILKMISLRQYYFTIGWNVFDFIVVILSIIGMFLSELIEKYLVSPTLFRVIRLARIGRILRLIKSAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKESGIDDMFNFETFGNSMICLFQITTSGGWDLLLAPILNKGEPDCDSRKEHPGSTYKGGDCGNPPVAIIFFVSYIIICFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDARATQFMEYDKLSDFADALDPPLRISKPNKIQLISMDLPMVSGERIHCLDILFAFTKRVLGEGEGLDILRGQMEERFMASNPSKVSYEPITTTLRRKLEDMSALVIQRAFRRYLLKRIVKRASAMYKEKMQSGGTLLDKEVLVIDKFNEISTSDRTDMTPSTASPPSYDSVTKPEKNKYKKDKRKKEVKEKKKYMDVGKI

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1S3PLV2A0A1S3PLV2_SALSALOC1065861961999
A0A1S3PLZ5A0A1S3PLZ5_SALSALOC1065861961875
A0A1S3PM38A0A1S3PM38_SALSALOC1065861961988
A0A1S3PMY2A0A1S3PMY2_SALSALOC1065861961999
A0A1S3PMZ4A0A1S3PMZ4_SALSALOC1065861961750

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias490-513Basic and acidic residues
Compositional bias583-598Basic and acidic residues
Compositional bias599-614Polar residues
Compositional bias1941-1959Polar residues

Keywords

Sequence databases

Similar Proteins

Disclaimer

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