A0A1S3GMJ9 · A0A1S3GMJ9_DIPOR

Function

function

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Note: Binds 1 Fe2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: The zinc ions have a structural role.

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular Componentcytoplasm
Cellular Componentfemale pronucleus
Cellular Componentmale pronucleus
Molecular Function5-methylcytosine dioxygenase activity
Molecular Functionmethyl-CpG binding
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Functionzinc ion binding
Biological Process5-methylcytosine catabolic process
Biological Processchromosomal 5-methylcytosine DNA demethylation pathway
Biological Processepigenetic programing of male pronucleus
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processprotein O-linked glycosylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Methylcytosine dioxygenase TET
  • EC number

Gene names

    • Name
      Tet3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Castorimorpha > Heteromyidae > Dipodomyinae > Dipodomys

Accessions

  • Primary accession
    A0A1S3GMJ9

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain50-90CXXC-type
Region136-175Disordered
Region229-251Disordered
Compositional bias370-385Polar residues
Region370-396Disordered
Region412-461Disordered
Compositional bias424-452Polar residues
Region486-614Disordered
Compositional bias514-528Polar residues
Compositional bias556-571Pro residues
Region636-707Disordered
Compositional bias641-671Pro residues
Compositional bias679-697Polar residues
Region1350-1467Disordered
Compositional bias1386-1401Polar residues
Compositional bias1430-1457Polar residues
Region1494-1537Disordered
Region1614-1634Disordered

Sequence similarities

Belongs to the TET family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,800
  • Mass (Da)
    194,520
  • Last updated
    2017-04-12 v1
  • Checksum
    654332665410D0AE
MSQFQMPLAVQPDLPGLYDFPQGQVMVGGFQGPGVSMAGSEAQLRGGGDGRKKRKRCGTCEPCRRLENCGACTSCTNRRTHQICKLRKCEMLKKKVGLLKEVEIKAGEGTGPWTQGAVLKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSTSGAPVNGAREPAGPSLLGAAGPWRVDQKPNWDAAPAPAHTARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMSREAGNNNRGPRPGPEGCPAGSEDLDTLQTALALARHGMKPPNCNCDGPECPDYLEWLEGKIKSVVMEGGQERPRLPGPLPPGDASLPAPSTRPLLSAEVPQVPPLEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHSTSQASCPLPEALSPSAPFRSPQSYLRAPSWPVVPPEEHPPFVPNSPAFPQATPRTEFSEAWGTETPPATNPRNSWPVSRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEASSSSPAPSPSPNLQREAPPPSSEPDTHQKAQTALQQHLHHKRSLFLEQARDASFPAPSEPPASGWWAPPSSPAPRPPDRPPKEKKKKPSTPAGALVGTEKATPGIKPSVRKPIQIKKSRSREVQPLFLPLRQIILEGLRSPASEEVQAPPPAPLPDPLPTTQGSAIPLPPEPSLALFAPSPSGDSLLPPTQEMRSPSPMAALQPGSTGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQDTENQPTCIPAPESPFATRSPKQIKIESSGAVTVLSTTCFHSEEVSQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKRAQAEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEERYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLAGDNPKEEEVLRKNFQGLATEVAPLYKQLAPQAYQNQVTNEEIAIDCRLGLKEGRPFSGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGQIPEDEQLHVLPLYKMANTDEFGSEENQNAKVSSGAIQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKIQKEKLSTPEKIKQEALELAGVPTDPGLALKGGLSQQSLKPSLKVEPQNHFSSFKYSSNAVVESYSVLGSCRPSDPYSMSSVYSYHSHYAQPSLASVNGFHAKYALPSFSYYGFPSSNPVFPSQFLGPGAWGHGGSNGSFEKKPDLHALHNSLSPAYGGAEFAELPGQAVTTDTHHPAPHHQQPAYPGPKDYLLPKAPQLHPASRDPSPFAQSSNCYNRSIKQEPVDPLAQAESVPRDSGKMGKTPLPEASQNGGPNHLWGQYSGGSSMSPKRTNSVGGSWGMFPRGESPAIGSDKLNSFGASCLTPAHFPDGQWGLFPGEGQPSTPHPGGRLRGKPWSPCKFGNSSSALAGPGLTEKPWGVGGADFNSALKGGPGFQDKLWNPMKGEEARIPTSSSSQLDKAWQAFGMPLGSSEKLFGALKSEEKLWDPFSLEEGTAEEPPSKGVVKEEKGGPVVEEEEEELWSDSEHNFLDENIGGVAVAPAHGSILIECARRELHATTPLKKPNRFHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARARQEEAARLGLGQQEAKLYGKKRKWGGAIVAESQNKEKKRAVPTRQALAMPTDSAVTVSSYAYTKVTGPYSRWI

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias370-385Polar residues
Compositional bias424-452Polar residues
Compositional bias514-528Polar residues
Compositional bias556-571Pro residues
Compositional bias641-671Pro residues
Compositional bias679-697Polar residues
Compositional bias1386-1401Polar residues
Compositional bias1430-1457Polar residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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