A0A1S3GMJ9 · A0A1S3GMJ9_DIPOR
- ProteinMethylcytosine dioxygenase TET
- GeneTet3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1800 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.
Catalytic activity
- 2-oxoglutarate + a 5-formyl-2'-deoxycytidine in DNA + O2 = a 5-carboxyl-2'-deoxycytidine in DNA + CO2 + H+ + succinate
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 Fe2+ ion per subunit.
Note: The zinc ions have a structural role.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | cytoplasm | |
Cellular Component | female pronucleus | |
Cellular Component | male pronucleus | |
Molecular Function | 5-methylcytosine dioxygenase activity | |
Molecular Function | methyl-CpG binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | zinc ion binding | |
Biological Process | 5-methylcytosine catabolic process | |
Biological Process | chromosomal 5-methylcytosine DNA demethylation pathway | |
Biological Process | epigenetic programing of male pronucleus | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | protein O-linked glycosylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethylcytosine dioxygenase TET
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Castorimorpha > Heteromyidae > Dipodomyinae > Dipodomys
Accessions
- Primary accessionA0A1S3GMJ9
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 50-90 | CXXC-type | ||||
Sequence: GRKKRKRCGTCEPCRRLENCGACTSCTNRRTHQICKLRKCE | ||||||
Region | 136-175 | Disordered | ||||
Sequence: MDSGPVYHGDSRQLSTSGAPVNGAREPAGPSLLGAAGPWR | ||||||
Region | 229-251 | Disordered | ||||
Sequence: SREAGNNNRGPRPGPEGCPAGSE | ||||||
Compositional bias | 370-385 | Polar residues | ||||
Sequence: LPQPSHSTSQASCPLP | ||||||
Region | 370-396 | Disordered | ||||
Sequence: LPQPSHSTSQASCPLPEALSPSAPFRS | ||||||
Region | 412-461 | Disordered | ||||
Sequence: EEHPPFVPNSPAFPQATPRTEFSEAWGTETPPATNPRNSWPVSRPSPDPM | ||||||
Compositional bias | 424-452 | Polar residues | ||||
Sequence: FPQATPRTEFSEAWGTETPPATNPRNSWP | ||||||
Region | 486-614 | Disordered | ||||
Sequence: PTKPKVKVEASSSSPAPSPSPNLQREAPPPSSEPDTHQKAQTALQQHLHHKRSLFLEQARDASFPAPSEPPASGWWAPPSSPAPRPPDRPPKEKKKKPSTPAGALVGTEKATPGIKPSVRKPIQIKKSR | ||||||
Compositional bias | 514-528 | Polar residues | ||||
Sequence: PPSSEPDTHQKAQTA | ||||||
Compositional bias | 556-571 | Pro residues | ||||
Sequence: PASGWWAPPSSPAPRP | ||||||
Region | 636-707 | Disordered | ||||
Sequence: PASEEVQAPPPAPLPDPLPTTQGSAIPLPPEPSLALFAPSPSGDSLLPPTQEMRSPSPMAALQPGSTGPLPP | ||||||
Compositional bias | 641-671 | Pro residues | ||||
Sequence: VQAPPPAPLPDPLPTTQGSAIPLPPEPSLAL | ||||||
Compositional bias | 679-697 | Polar residues | ||||
Sequence: DSLLPPTQEMRSPSPMAAL | ||||||
Region | 1350-1467 | Disordered | ||||
Sequence: VTTDTHHPAPHHQQPAYPGPKDYLLPKAPQLHPASRDPSPFAQSSNCYNRSIKQEPVDPLAQAESVPRDSGKMGKTPLPEASQNGGPNHLWGQYSGGSSMSPKRTNSVGGSWGMFPRG | ||||||
Compositional bias | 1386-1401 | Polar residues | ||||
Sequence: DPSPFAQSSNCYNRSI | ||||||
Compositional bias | 1430-1457 | Polar residues | ||||
Sequence: ASQNGGPNHLWGQYSGGSSMSPKRTNSV | ||||||
Region | 1494-1537 | Disordered | ||||
Sequence: QWGLFPGEGQPSTPHPGGRLRGKPWSPCKFGNSSSALAGPGLTE | ||||||
Region | 1614-1634 | Disordered | ||||
Sequence: EEGTAEEPPSKGVVKEEKGGP |
Sequence similarities
Belongs to the TET family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,800
- Mass (Da)194,520
- Last updated2017-04-12 v1
- Checksum654332665410D0AE
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 370-385 | Polar residues | ||||
Sequence: LPQPSHSTSQASCPLP | ||||||
Compositional bias | 424-452 | Polar residues | ||||
Sequence: FPQATPRTEFSEAWGTETPPATNPRNSWP | ||||||
Compositional bias | 514-528 | Polar residues | ||||
Sequence: PPSSEPDTHQKAQTA | ||||||
Compositional bias | 556-571 | Pro residues | ||||
Sequence: PASGWWAPPSSPAPRP | ||||||
Compositional bias | 641-671 | Pro residues | ||||
Sequence: VQAPPPAPLPDPLPTTQGSAIPLPPEPSLAL | ||||||
Compositional bias | 679-697 | Polar residues | ||||
Sequence: DSLLPPTQEMRSPSPMAAL | ||||||
Compositional bias | 1386-1401 | Polar residues | ||||
Sequence: DPSPFAQSSNCYNRSI | ||||||
Compositional bias | 1430-1457 | Polar residues | ||||
Sequence: ASQNGGPNHLWGQYSGGSSMSPKRTNSV |
Keywords
- Technical term