A0A1S3ESQ3 · A0A1S3ESQ3_DIPOR
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- GenePlcb1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1216 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 331 | ||||
Binding site | 332 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 361 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 363 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 378 | ||||
Binding site | 412 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Castorimorpha > Heteromyidae > Dipodomyinae > Dipodomys
Accessions
- Primary accessionA0A1S3ESQ3
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 469-534 | Disordered | |||
Compositional bias | 480-500 | Polar residues | |||
Compositional bias | 507-521 | Acidic residues | |||
Domain | 540-656 | PI-PLC Y-box | |||
Domain | 656-784 | C2 | |||
Region | 834-891 | Disordered | |||
Compositional bias | 851-883 | Polar residues | |||
Compositional bias | 963-982 | Basic and acidic residues | |||
Region | 963-994 | Disordered | |||
Region | 1071-1095 | Disordered | |||
Region | 1172-1216 | Disordered | |||
Compositional bias | 1195-1216 | Basic and acidic residues | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,216
- Mass (Da)138,472
- Last updated2017-04-12 v1
- MD5 Checksum95932F13E1B6B03B9998A513F141DE8D
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1S3EPZ0 | A0A1S3EPZ0_DIPOR | Plcb1 | 1173 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 480-500 | Polar residues | |||
Compositional bias | 507-521 | Acidic residues | |||
Compositional bias | 851-883 | Polar residues | |||
Compositional bias | 963-982 | Basic and acidic residues | |||
Compositional bias | 1195-1216 | Basic and acidic residues | |||
Keywords
- Technical term