A0A1S2N517 · A0A1S2N517_9MICC

  • Protein
    Lipoprotein signal peptidase
  • Gene
    lspA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

This protein specifically catalyzes the removal of signal peptides from prolipoproteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.
    EC:3.4.23.36 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; lipoprotein biosynthesis (signal peptide cleavage).

Features

Showing features for active site.

119420406080100120140160180
TypeIDPosition(s)Description
Active site132
Active site146

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionaspartic-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoprotein signal peptidase
  • EC number
  • Alternative names
    • Prolipoprotein signal peptidase
    • Signal peptidase II
      (SPase II
      )

Gene names

    • Name
      lspA
    • ORF names
      BK826_01005

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • LCT-H5
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Micrococcaceae > Rothia

Accessions

  • Primary accession
    A0A1S2N517

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane73-92Helical
Transmembrane99-116Helical
Transmembrane136-161Helical

Keywords

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region170-194Disordered

Sequence similarities

Belongs to the peptidase A8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    194
  • Mass (Da)
    20,835
  • Last updated
    2017-04-12 v1
  • Checksum
    58F79C9BBA1B9F1C
MSSHHPARPTRPRVGLVVSAVILGVLLYAADQASKAWVVAHMVEGQRITVIPDLLWWRFLRNPGAAFSLGESVTWVFTLVQTAVAVVVIRLLPRARSAAWLLSLTGLLAGVLGNLTDRLFRQPGFGRGHVVDFISVPHFAIFNIADSCICVSIAVIAVLTLRGVPLEGRDPEAAVPGPADDARAAAEHAEETRP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MODZ01000001
EMBL· GenBank· DDBJ
OIJ37025.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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