A0A1S2N450 · A0A1S2N450_9MICC

  • Protein
    Probable cytosol aminopeptidase
  • Gene
    pepA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.
    EC:3.4.11.1 (UniProtKB | ENZYME | Rhea)
  • Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.
    EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 2 manganese ions per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site267Mn2+ 2 (UniProtKB | ChEBI)
Binding site272Mn2+ 1 (UniProtKB | ChEBI)
Binding site272Mn2+ 2 (UniProtKB | ChEBI)
Active site279
Binding site290Mn2+ 2 (UniProtKB | ChEBI)
Binding site349Mn2+ 1 (UniProtKB | ChEBI)
Binding site351Mn2+ 2 (UniProtKB | ChEBI)
Binding site351Mn2+ 1 (UniProtKB | ChEBI)
Active site353

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionmanganese ion binding
Molecular Functionmetalloaminopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable cytosol aminopeptidase
  • EC number
  • Alternative names
    • Leucine aminopeptidase
      (LAP
      ) (EC:3.4.11.10
      ) . EC:3.4.11.10 (UniProtKB | ENZYME | Rhea)
    • Leucyl aminopeptidase

Gene names

    • Name
      pepA
    • ORF names
      BK826_00895

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • LCT-H5
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Micrococcaceae > Rothia

Accessions

  • Primary accession
    A0A1S2N450

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain347-354Cytosol aminopeptidase

Sequence similarities

Belongs to the peptidase M17 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    506
  • Mass (Da)
    52,353
  • Last updated
    2017-04-12 v1
  • Checksum
    30D14ED92859C1A0
MTESHDLALSVTAPDDGLEVRALVVGVLPAGQGARLAPHHLPEETAEGLQAVLSDLGITGARDEVHRLPGAESTGADVLVLVGLGELPEEGRERLDALRYAAGSAIRQLQGMDTAALDLPVADLAEVGALAEGAAFGAFVDPMYRTGTADRELSPVGEVVILTDVEAQEAEPVLTRALILGEAVDSTRRLVNEAPNHLYPDSFAGRVLERVAGIDDVEVEVLDEQALAEGGFGGILGVGRGSHRPPRLVVVDYRPEGAGQHMALVGKGITFDSGGLSLKPGTGMMTMKSDMAGAAAVLNAVAAAAELRLPLRVTGYLCLAENLPGGGATRPEDVLVMRGGTTVEVLNTDAEGRLVMADGLAYASEQSPDCLLDVATLTGAQVVALGERYAAVMGEDSLREAVAQAGAEAGEPFWPMPLPEELRAGLKSPVADLKNIGAGRAGGMLTAGLFLQRFVGQVDGQPIPWAHLDIAGPSFNEGSEYGFTPKQGTGVAVRTLITLAERIAAA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MODZ01000001
EMBL· GenBank· DDBJ
OIJ37007.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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