A0A1S2N0Y0 · A0A1S2N0Y0_9MICC
- ProteinLysosomal dipeptide transporter MFSD1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids464 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.
Catalytic activity
- L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
- L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
- L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
- L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
- L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
- L-arginyl-glycine(out) = L-arginyl-glycine(in)
- L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
- L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
- L-histidyl-glycine(out) = L-histidyl-glycine(in)
- L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
- L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
- L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
- L-lysyl-glycine(out) = L-lysyl-glycine(in)
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | lysosomal membrane | |
Molecular Function | transmembrane transporter activity |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameLysosomal dipeptide transporter MFSD1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Micrococcales > Micrococcaceae > Rothia
Accessions
- Primary accessionA0A1S2N0Y0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Lysosome membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 20-38 | Helical | ||||
Sequence: IIWSVGLAAYLVAVINRSS | ||||||
Transmembrane | 50-71 | Helical | ||||
Sequence: FSAEATALSVFVVVQLVVYAGW | ||||||
Transmembrane | 83-105 | Helical | ||||
Sequence: GISAVIAAGTAVMAVGQLLLGAT | ||||||
Transmembrane | 112-133 | Helical | ||||
Sequence: ILARILVGSGDACIFTAVVRLV | ||||||
Transmembrane | 173-195 | Helical | ||||
Sequence: WFAGFAALAAMGAAVLVLVLLVL | ||||||
Transmembrane | 261-282 | Helical | ||||
Sequence: LAFWIHFSTVFAMHSFMLLWGT | ||||||
Transmembrane | 294-314 | Helical | ||||
Sequence: ATSHLVLSLTVGASMVGAVLL | ||||||
Transmembrane | 326-346 | Helical | ||||
Sequence: VWIAVGGTTAILLTWVVVLVW | ||||||
Transmembrane | 352-373 | Helical | ||||
Sequence: VPVMTIAAVCTGLGGPLSMIAF | ||||||
Transmembrane | 385-411 | Helical | ||||
Sequence: LGVATGLTNMGGFTAALTTVLLVGVLL | ||||||
Transmembrane | 426-447 | Helical | ||||
Sequence: AFRWAMAVQVPVWLLGLTMMLI |
Keywords
- Cellular component
Interaction
Subunit
Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 21-453 | Major facilitator superfamily (MFS) profile | ||||
Sequence: IWSVGLAAYLVAVINRSSFSALGPAAQEHFSAEATALSVFVVVQLVVYAGWQIPVGILLDRFGISAVIAAGTAVMAVGQLLLGATGSIPLAILARILVGSGDACIFTAVVRLVQDWFTLGQMPVVNQLTGLSGQVGQLLAVAPLAALVAGLGWFAGFAALAAMGAAVLVLVLLVLRDAPGAGTILERITGANRTTGRDVAAARAGQRTDSVVTDVLPVIGPESTGVLPALRSLVRRPGVRLAFWIHFSTVFAMHSFMLLWGTPFMTGGLGYSEATSHLVLSLTVGASMVGAVLLGPVISRFSAHRVWIAVGGTTAILLTWVVVLVWPGSAPVPVMTIAAVCTGLGGPLSMIAFDVVRTHAPVRQLGVATGLTNMGGFTAALTTVLLVGVLLDAQGAGTPETYSSAAFRWAMAVQVPVWLLGLTMMLIERPKAR |
Sequence similarities
Belongs to the major facilitator superfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length464
- Mass (Da)48,270
- Last updated2017-04-12 v1
- ChecksumA831E64D0B0412E8