A0A1S2N0Y0 · A0A1S2N0Y0_9MICC

  • Protein
    Lysosomal dipeptide transporter MFSD1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
  • L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)
  • L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)
  • L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)
  • L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)
  • L-arginyl-glycine(out) = L-arginyl-glycine(in)
  • L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
  • L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)
  • L-histidyl-glycine(out) = L-histidyl-glycine(in)
  • L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)
  • L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)
  • L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)
  • L-lysyl-glycine(out) = L-lysyl-glycine(in)

GO annotations

AspectTerm
Cellular Componentlysosomal membrane
Molecular Functiontransmembrane transporter activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Lysosomal dipeptide transporter MFSD1
  • Alternative names
    • Major facilitator superfamily domain-containing protein 1

Gene names

    • ORF names
      BK826_02785

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • LCT-H5
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Micrococcales > Micrococcaceae > Rothia

Accessions

  • Primary accession
    A0A1S2N0Y0

Proteomes

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-38Helical
Transmembrane50-71Helical
Transmembrane83-105Helical
Transmembrane112-133Helical
Transmembrane173-195Helical
Transmembrane261-282Helical
Transmembrane294-314Helical
Transmembrane326-346Helical
Transmembrane352-373Helical
Transmembrane385-411Helical
Transmembrane426-447Helical

Keywords

Interaction

Subunit

Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain21-453Major facilitator superfamily (MFS) profile

Sequence similarities

Belongs to the major facilitator superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    464
  • Mass (Da)
    48,270
  • Last updated
    2017-04-12 v1
  • Checksum
    A831E64D0B0412E8
MHESVPASGIAAQPPSRKWIIWSVGLAAYLVAVINRSSFSALGPAAQEHFSAEATALSVFVVVQLVVYAGWQIPVGILLDRFGISAVIAAGTAVMAVGQLLLGATGSIPLAILARILVGSGDACIFTAVVRLVQDWFTLGQMPVVNQLTGLSGQVGQLLAVAPLAALVAGLGWFAGFAALAAMGAAVLVLVLLVLRDAPGAGTILERITGANRTTGRDVAAARAGQRTDSVVTDVLPVIGPESTGVLPALRSLVRRPGVRLAFWIHFSTVFAMHSFMLLWGTPFMTGGLGYSEATSHLVLSLTVGASMVGAVLLGPVISRFSAHRVWIAVGGTTAILLTWVVVLVWPGSAPVPVMTIAAVCTGLGGPLSMIAFDVVRTHAPVRQLGVATGLTNMGGFTAALTTVLLVGVLLDAQGAGTPETYSSAAFRWAMAVQVPVWLLGLTMMLIERPKARREHLKRLHRAR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MODZ01000003
EMBL· GenBank· DDBJ
OIJ36373.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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