A0A1S2MK83 · A0A1S2MK83_9STAP

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

1845100200300400500600700800
TypeIDPosition(s)Description
Binding site91ATP (UniProtKB | ChEBI)
Binding site109-113ATP (UniProtKB | ChEBI)
Binding site498ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • ORF names
      BK821_06205

Organism names

  • Taxonomic identifier
  • Strain
    • LCT-H4
  • Taxonomic lineage
    Bacteria > Bacillati > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    A0A1S2MK83

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Membrane
; Peripheral membrane protein
Note: Distribution is 50-50.

Keywords

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain1-576SecA family profile
Domain93-251Helicase ATP-binding
Domain420-581Helicase C-terminal
Region793-836Disordered
Compositional bias803-827Basic and acidic residues

Sequence similarities

Belongs to the SecA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    845
  • Mass (Da)
    95,886
  • Last updated
    2017-04-12 v1
  • MD5 Checksum
    178B6C87DE1A916DBFBAEE8408C4A935
MGFLSKIADGNKKEIKRLGKLADKVLALEEDMSILTDEEIREKTKAFQAKLREEEDVKKQNKMLDDILPEAFAIVREGSKRVFNMIPYKVQVMGGIAIHNGDISEMRTGEGKTLTATMPTYLNALTGRGVHVITVNEYLASSQSEEMAELYEFLGLSVGLNLNSKSTDEKREAYASDITYSTNNELGFDYLRDNMVNYAEERVMRPLHYAIIDEVDSILIDEARTPLIISGEAEKSTSLYTQANVFAKMLKNEDDYNFDEKTKAVQLTEQGTDKAERMFKIDNLYDVKNVDIISHINTALRAHVTLQKDVDYMVNAGEVLIVDQFTGRTMPGRRFSEGLHQAIEAKEGVKIQNESKTMASITFQNYFRMYNKLSGMTGTAKTEEEEFRNIYNMTVTQIPTNKPVQRIDKPDLIYISQKGKFDAVVADVIEKHKLGQPVLLGTVAVETSEYISNLLKKNGVRHDVLNAKNHEREAEIVAGAGERGAVTIATNMAGRGTDIKLGAGVEEIGGLAVIGTERHESRRIDDQLRGRSGRQGDRGDSRFYLSLQDELMVRFGSERLQSMMNRLGMDDSTPIESKMVSRAVESAQKRVEGNNFDARKRVLEYDDVLRKQREIIYTERNRIIDSDASGELVNAMLRSTLERSVHYHVNDEDDEPDYEPFINYVDDVFLNEGDLKEEEIKGKDKEDIFDVVWSKVEVGLKDQKEKIGSQFDEFERMILLRSIDNHWTDHIDTMDQLRQGIHLRSYGQQNPLRDYQNEGHQLFDTMMENIEEDVSKFILKSVVSVEDDLERDKTTNFGNAEHVSADGDNSKEDTKSEPFVKDEHVGRNDPCPCGSGKKYKNCHGA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias803-827Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MODY01000002
EMBL· GenBank· DDBJ
OIJ30155.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice.
Help