A0A1S2MG87 · A0A1S2MG87_9STAP

  • Protein
    Ribosomal RNA small subunit methyltransferase A
  • Gene
    rsmA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site30S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site32S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site57S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site78S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site103S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site128S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Molecular Function23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity
Molecular FunctionRNA binding

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribosomal RNA small subunit methyltransferase A
  • EC number
  • Alternative names
    • 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase
    • 16S rRNA dimethyladenosine transferase
    • 16S rRNA dimethylase
    • S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase

Gene names

    • Name
      rsmA
    • Synonyms
      ksgA
    • ORF names
      BK821_12610

Organism names

  • Taxonomic identifier
  • Strain
    • LCT-H4
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Staphylococcaceae > Staphylococcus

Accessions

  • Primary accession
    A0A1S2MG87

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain37-213Ribosomal RNA adenine methylase transferase N-terminal

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    296
  • Mass (Da)
    33,478
  • Last updated
    2017-04-12 v1
  • Checksum
    DDEDEFB0F5B3C224
MDIKDIATPSRTKALLNQYGFNFKKSLGQNFLIDVNIIHNIIDASDIDENTGVIEIGPGMGSLTEQLAKSAKKVIAFEIDQRLIPVLKDTMSPYDNVIVINEDILKANIAQYVSDNLADCDKIMVVANLPYYITTPILLNLMQQRLPIDGYVVMMQKEVGERLNAQVGTKAYGSLSIVAQYYTETSQVLTVPKSVFLPPPNVDSIVVKLMKRDVPQVEVDNEDKFFKMTKSAFSQRRKTINNNYQSLFVEGKNKKEVILKWLETSGIDPIRRGETLSIKEFANLYNELKNFPELEF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MODY01000008
EMBL· GenBank· DDBJ
OIJ29011.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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