A0A1S1J2N1 · A0A1S1J2N1_9FLAO

  • Protein
    Phosphoribosylformylglycinamidine synthase
  • Gene
    purL
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site260-271ATP (UniProtKB | ChEBI)
Binding site676Mg2+ (UniProtKB | ChEBI)
Binding site680Mg2+ (UniProtKB | ChEBI)
Binding site838Mg2+ (UniProtKB | ChEBI)
Active site1078Nucleophile
Active site1191
Active site1193

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionphosphoribosylformylglycinamidine synthase activity
Biological Process'de novo' IMP biosynthetic process
Biological Processglutamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylformylglycinamidine synthase
  • EC number
  • Short names
    FGAM synthase
    ; FGAMS
  • Alternative names
    • Formylglycinamide ribonucleotide amidotransferase
      (FGAR amidotransferase
      ; FGAR-AT
      )

Gene names

    • Name
      purL
    • ORF names
      BHE19_09240

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MSU
  • Taxonomic lineage
    Bacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae > Flavobacterium

Accessions

  • Primary accession
    A0A1S1J2N1

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-88Phosphoribosylformylglycinamidine synthase N-terminal
Domain122-171Phosphoribosylformylglycinamidine synthase linker
Domain392-546PurM-like C-terminal
Domain776-917PurM-like C-terminal

Sequence similarities

In the N-terminal section; belongs to the FGAMS family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,229
  • Mass (Da)
    135,494
  • Last updated
    2017-04-12 v1
  • Checksum
    738FB35F2F3BA6DF
MIHFFENQSKTVFAVQTQNEISAQDISKLNWLFADSNKIEKSALTDFFVGPRATMITPWSTNAVEITQNMGITGIIRIEEFHPATADFSDFDPMLLQKFSQLDQEIFTINVQPEPILEIDDIAAYNTTEGLALSEEEVDYLNNLSTKLGRKLTDSEIFAFSQANSEHCRHKIFNGTFVIDGEEKETSLFKLIKKTSQENPNDIVSAYKDNVAFVKGPKVQQFAPKTADKPDFYEIKEFDSVISLKAETHNFPTTVEPFNGAATGSGGEIRDRLAGGQGSLPLAGTAVYMTSYSRLKSFDSAQPFDSAQGDRKWENAVEERKWLYQTPMDILIKASNGASDFGNKFGQPLITGSVLTFEHSENDRKIGYDKVIMQAGGIGYGKLDQSIKKKPQEGDKIVILGGENYRIGMGGAAVSSADTGAFGSGIELNAIQRSNPEMQKRAANAIRGLVESDNNPIVSIHDHGAGGHLNCLSELVEETGGLIDLDKLPVGDPTLSAKEIIGNESQERMGLVIGQKDIDTLQRIADRERSPMYQVGDVTGDHRFTFESKTNGSKPMDYALEDFFGSSPKTVMTDKTIDRKYADVAYNTADFESYLQDVLRLEAVASKDWLTNKVDRCVGGKVAKQQNAGPLQLPLNNVGVMALDYLGKEGIATSIGHAPIAALIDPVAGSRNAIAESLSNIIWAPIKDQLKGISLSANWMWACKNEGEDARLYAAVEGCSEFAIELGINIPTGKDSLSMKQKYPNDEVIAPGTVIISAAGNCTDIRKVVEPVLQRNGDSIYYINLSQDDFKLGGSSFAQIRNTIGKETSTIKDASFFKNAFNTIQELIGDNQILAGHDIGSGGLITTLLELCFADVNLGAKIDFSAFAEKDLLKILFAENIGIVFQAKSNAAVEAKLKSNNIEFFKIGSVQETASLEFGIYNLDIAKYRDIWFETSYLLDQKQSKNGRAQARFENYKNQALNYTFPAHFTGKAPVISSGVERPKAAIIREKGSNSEREMANAMYLAGFDVKDVHMTDLISGRETLEDIQFIGAVGGFSNSDVLGSAKGWAGAFLYNEKAKTALDNFFKREDTLSVGICNGCQLFMELEVINPEHEVHGKMLHNESQKHESIFTSVKVQENNSVMLSTLAGSTLGVWVSHGEGKFKLPLAEENYNIVSKYAYEGYPANPNGSDYNTAMLCDKTGRHLVMMPHIERSTFQWNWAHYPKDRNDEVSPWHEAFVNARKWIEKN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MIKE01000023
EMBL· GenBank· DDBJ
OHT44892.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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