A0A1R7T1H4 · A0A1R7T1H4_9FLAV
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids3393 (go to sequence)
- Protein existencePredicted
- Annotation score5/5
Function
function
Component of the viral RNA replication complex that functions in virion assembly and antagonizes the host immune response.
Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1527 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: H | ||||||
Active site | 1551 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: D | ||||||
Active site | 1611 | Charge relay system; for serine protease NS3 activity | ||||
Sequence: S | ||||||
Binding site | 2550 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 2580 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 2581 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: W | ||||||
Binding site | 2598 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 2599 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: K | ||||||
Binding site | 2625 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 2626 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 2712 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 2931 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 2935 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 2940 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 2943 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3205 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 3221 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 3340 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C |
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Kitrinoviricota > Flasuviricetes > Amarillovirales > Flaviviridae > Orthoflavivirus > Orthoflavivirus denguei > Dengue virus
Accessions
- Primary accessionA0A1R7T1H4
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Multi-pass membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Multi-pass membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Host endoplasmic reticulum membrane ; Peripheral membrane protein
Membrane ; Multi-pass membrane protein
Membrane ; Peripheral membrane protein
Virion membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 725-749 | Helical | ||||
Sequence: YGVLFSGVSWTMKIGIGILLTWLGL | ||||||
Transmembrane | 756-774 | Helical | ||||
Sequence: LSMTCIAVGMVTLYLGVMV | ||||||
Transmembrane | 1159-1178 | Helical | ||||
Sequence: MLMTGTLAVFFLLIMGQLTW | ||||||
Transmembrane | 1202-1222 | Helical | ||||
Sequence: YLALMATFKMRPMFAVGLLFR | ||||||
Transmembrane | 1295-1313 | Helical | ||||
Sequence: TMAMVLSIVSLFPLCLSTT | ||||||
Transmembrane | 1319-1338 | Helical | ||||
Sequence: WLPVLLGSLGCKPLTMFLIA | ||||||
Transmembrane | 1374-1391 | Helical | ||||
Sequence: LAGPLIAGGMLIACYVIS | ||||||
Transmembrane | 1443-1470 | Helical | ||||
Sequence: ILLKATLLAVSGVYPLSIPATLFVWYFW | ||||||
Transmembrane | 2150-2169 | Helical | ||||
Sequence: LMLLALIAVLTGGVTLFFLS | ||||||
Transmembrane | 2176-2193 | Helical | ||||
Sequence: TSIGLLCVMASSALLWMA | ||||||
Transmembrane | 2199-2216 | Helical | ||||
Sequence: WIAASIILEFFLMVLLIP | ||||||
Transmembrane | 2228-2245 | Helical | ||||
Sequence: QLAYVVIGLLFMILTVAA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 284↔311 | |||||
Sequence: CVGIGNRDFVEGLSGATWVDVVLEHGSC | ||||||
Disulfide bond | 341↔397 | |||||
Sequence: CIEAKISNTTTDSRCPTQGEATLVEEQDTNFVCRRTFVDRGWGNGCGLFGKGSLITC | ||||||
Disulfide bond | 355↔386 | |||||
Sequence: CPTQGEATLVEEQDTNFVCRRTFVDRGWGNGC | ||||||
Disulfide bond | 373↔402 | |||||
Sequence: CRRTFVDRGWGNGCGLFGKGSLITCAKFKC | ||||||
Disulfide bond | 466↔566 | |||||
Sequence: CSPRTGLDFNEMVLLTMKEKSWLVHKQWFLDLPLPWTSGASTSQETWNRQDLLVTFKTAHAKKQEVVVLGSQEGAMHTALTGATEIQTSGTTTIIAGHLKC | ||||||
Disulfide bond | 583↔614 | |||||
Sequence: CTGSFKLEKEVAETQHGTVLVQVKYEGTDAPC |
Keywords
- PTM
Interaction
Subunit
Interacts (via N-terminus) with serine protease NS3.
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1347-1476 | Flavivirus NS2B | ||||
Sequence: SWPLNEGIMAVGIVSILLSSLLKNDVPLAGPLIAGGMLIACYVISGSSADLSLEKAAEVSWEEEAEHSGTSHNILVEVQDDGTMKIKDEERDDTLTILLKATLLAVSGVYPLSIPATLFVWYFWQKKKQR | ||||||
Domain | 1477-1654 | Peptidase S7 | ||||
Sequence: SGVLWDTPSPPKVERAVLDNGIYRIMQRGLLGRSQVGVGVFQEGVFHTMWHVTRGAVLMYQGKRLEPSWASVKKDLISYGGGWRLQGSWNTGEEVQVIAVEPGKNPKNVQTTPGTFKTPEGEVGAIALDFKPGTSGSPIVNREGKIVGLYGNGVVTTSGTYVSAIAQAKASQEGPLPE | ||||||
Domain | 1657-1813 | Helicase ATP-binding | ||||
Sequence: DEVFRKRNLTIMDLHPGSGKTRRYLPAIVREAIKRKLRTLILAPTRVVASEMAEALKGMPIRYQTTAVKSEHTGKEIVDLMCHATFTMRLLSPVRVPNYNMIIMDEAHFTDPASIAARGYISTRVGMGEAAAIFMTATPPGSVEAFPQSNAVIQDEE | ||||||
Domain | 1823-1989 | Helicase C-terminal | ||||
Sequence: SGYEWITDFPGKTVWFVPSIKSGNDIANCLRKNGKRVVQLSRKTFDTEYQKTKNNDWDYVVTTDISEMGANFRADRVIDPRRCLKPVILKDGPERVILAGPMPVTVASAAQRRGRIGRNPNKEGDQYVYMGQPLNNDEDHAHWTEAKMLLDNINTPEGIIPALFEPE | ||||||
Domain | 2496-2757 | MRNA cap 0-1 NS5-type MT | ||||
Sequence: TGAQGETLGEKWKRQLNQLSKSEFNIYKRSGIIEVDRSEAKEGLKRGETTKHAVSRGTAKLRWFVERNLVKPEGKVIDLGCGRGGWSYYCAGLKKVTEVKGYTKGGPGHEEPIPMATYGWNLVKLHSGKDVFFTPPEKCDTLLCDIGESSPNPTIEEGRTLRVLKMVEPWLRGNQFCIKILNPYMPSVVETLEKMQRKHGGMLVRNPLSRNSTHEMYWVSCGTGNIVSAVNMTSRMLLNRFTMAHRKPTYERDVDLGAGTRH | ||||||
Domain | 3021-3170 | RdRp catalytic | ||||
Sequence: GNMYADDTAGWDTRITEDDLQNEAKITDIMEPEHALLATSIFKLTYQNKVVRVQRPAKNGTVMDVISRRDQRGSGQVGTYGLNTFTNMEAQLIRQMESEGIFSPSELETPNLAERVFDWLEKHGIERLKRMAISGDDCVVKPIDDRFATA |
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,393
- Mass (Da)378,815
- Last updated2017-04-12 v1
- Checksum667C99CC6A6814AB