A0A1R7QA01 · A0A1R7QA01_ACIJO

Function

function

Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.

Catalytic activity

  • Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions.
    EC:3.1.26.12 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per homotetramer.

Features

Showing features for binding site.

111601002003004005006007008009001,0001,100
TypeIDPosition(s)Description
Binding site300Mg2+ (UniProtKB | ChEBI); catalytic
Binding site343Mg2+ (UniProtKB | ChEBI); catalytic
Binding site401Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners
Binding site404Zn2+ (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoplasmic side of plasma membrane
Molecular Functionmagnesium ion binding
Molecular Functionribonuclease E activity
Molecular FunctionRNA endonuclease activity
Molecular FunctionrRNA binding
Molecular FunctiontRNA binding
Molecular Functionzinc ion binding
Biological ProcessmRNA catabolic process
Biological ProcessrRNA processing
Biological ProcesstRNA processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease E
  • EC number
  • Short names
    RNase E

Gene names

    • Name
      rne
    • ORF names
      ACNJC6_00698

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • C6
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Moraxellales > Moraxellaceae > Acinetobacter

Accessions

  • Primary accession
    A0A1R7QA01

Proteomes

Subcellular Location

Cytoplasm
Cell inner membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation. Within the RNA degradosome, RNase E assembles into a homotetramer formed by a dimer of dimers.

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain39-117S1 motif
Region401-404Required for zinc-mediated homotetramerization and catalytic activity
Region525-561Disordered
Compositional bias536-561Polar residues
Region628-797Disordered
Compositional bias631-650Basic and acidic residues
Compositional bias659-743Basic and acidic residues
Compositional bias757-782Basic and acidic residues
Region869-917Disordered
Compositional bias878-901Basic and acidic residues
Compositional bias902-917Polar residues
Region991-1018Disordered
Region1027-1046Disordered
Region1053-1072Disordered
Region1105-1160Disordered
Compositional bias1113-1145Basic and acidic residues

Sequence similarities

Belongs to the RNase E/G family. RNase E subfamily.
Belongs to the RNase E/G family. RNase G subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,160
  • Mass (Da)
    129,621
  • Last updated
    2017-04-12 v1
  • Checksum
    B25EE0019ABACAD2
MKRMLINATHAEEIRVALVTGQRLYDFDLENRTREQKKSNIYKGHVTRVEPSLEAVFVEYGAGRQGFLSMREIANSYYQADPRQTSNIRELITEGTELLVQVEKEERGNKGAALSTFISLAGRYLVLMPNNPKGGGISRQISGSVREELKEMLASLNVPRGMSVIVRTAGIGRSQEELQLDLQHLLDLWAQIQNTASSGPSPMLVHQEAGVVTRAIRDYLRDDVAEILIDSEQAYNEAYNFVKAVMPRQIDKLKTYTLNEPLFAHFGIESQIQTAYEREVKLPSGGSIVIDQTEALVSIDINSAKSTRGSDVEDTALNTNLEAAEEIARQLRLRDIGGLVVIDFIDMTKDRNQRMVEAKLREATQSDRARIQFGQLSRFGLMEMSRQRLRPSLEEATGYVCPRCHGTGMVRDLRSLSLSIMRKVEEIALRERHGEVQVQVPVEIAAFLLNEKRHTLVYLEQTSGVRVTVLPHPHLETPHYEISYNPEGFAPTSYERTEATRSSEKELGYESSEWHLDGADHVHQHAAPAPVQQEKGNKKPRNNAPQQQVAQQAPAQTAPSSSPCAWLENLFVQKQAATVDQSRSANNAAAAIEQMVNGGAVSRGQFGQVGTPAAAPVAPSNNVYMSSAPVHAKSEHREDKHVEKEERGTRHNKKRPNKHKESREQNAQHDNQVHEEIVQVSRQDQQRQDRYEQRPERNEPQRQDRHEQRSERSEQQRQDRPERSEQQRQEPRENKRSSRRQHGEQQQNTDVQNEQQNAMPRRDRRNQPRPERPNRHRDPSVLNDQATEAAPAVVQEPQVKVELIEAPRQEMITTAHVVNVDQAQSEIVALTPSVHTATETKPQQAAVAKAEVEVKAEKVVQEKATEVVAAPAEQQAEQKPRESVKRASNDPRQRRRQQRAAHTQQTETPKLTPSQVPTLGQYTISSLIRHVYGEDCSVLIEQFGLIPTFNRALQKFTEEYAATLSKTVTTSAVEAEKKPVTRDVEITKAQPEAEPVPVLDLTPPAPVSEQRVANDPRERRRLAKLAAEQAKQARETAPVAESSAPETAVVAETPAAEAAPAVTPEENEPALVTESEAPIAVESSEVKSLADVAAVEEVEVVVAPVQAKAPRASKQAEKAEVTETVAETAADESDKSDSDKPVRPRRPRGRPPKKASPTES

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias536-561Polar residues
Compositional bias631-650Basic and acidic residues
Compositional bias659-743Basic and acidic residues
Compositional bias757-782Basic and acidic residues
Compositional bias878-901Basic and acidic residues
Compositional bias902-917Polar residues
Compositional bias1113-1145Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FUUY01000002
EMBL· GenBank· DDBJ
SJX21089.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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