A0A1R4AAV1 · A0A1R4AAV1_BABMR
- ProteinBifunctional dihydrofolate reductase-thymidylate synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids502 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism.
Catalytic activity
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP = 7,8-dihydrofolate + dTMP
Pathway
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 384 | |||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | mitochondrion | |
Molecular Function | dihydrofolate reductase activity | |
Molecular Function | thymidylate synthase activity | |
Biological Process | dTMP biosynthetic process | |
Biological Process | methylation | |
Biological Process | one-carbon metabolic process | |
Biological Process | tetrahydrofolate biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional dihydrofolate reductase-thymidylate synthase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Piroplasmida > Babesiidae > Babesia
Accessions
- Primary accessionA0A1R4AAV1
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-176 | DHFR | ||||
Sequence: KVCSIYASTPNGGIGNEGKLPWKTLPRDLKHLQDITTAYGPDHSVQNVVIMGRKTYISIPKSSRPLKDRINIVLSSSVSDFGDGVIAAKSMQDAFDKLEKMKFNKIFIIGGSSVYKEAYDLGIVEKVYVTRVNKELPADTFVTSVPPIFEIVGISRTFSYNDIPFDFIIYML |
Sequence similarities
In the C-terminal section; belongs to the thymidylate synthase family.
In the N-terminal section; belongs to the dihydrofolate reductase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length502
- Mass (Da)56,930
- Last updated2017-04-12 v1
- Checksum38163E795867F40C
Keywords
- Technical term