A0A1R4AAV1 · A0A1R4AAV1_BABMR

  • Protein
    Bifunctional dihydrofolate reductase-thymidylate synthase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism.

Catalytic activity

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site384

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmitochondrion
Molecular Functiondihydrofolate reductase activity
Molecular Functionthymidylate synthase activity
Biological ProcessdTMP biosynthetic process
Biological Processmethylation
Biological Processone-carbon metabolic process
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional dihydrofolate reductase-thymidylate synthase

Gene names

    • ORF names
      BMR1_02g03680

Organism names

  • Taxonomic identifier
  • Strain
    • RI
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Piroplasmida > Babesiidae > Babesia

Accessions

  • Primary accession
    A0A1R4AAV1

Proteomes

Organism-specific databases

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-176DHFR

Sequence similarities

In the C-terminal section; belongs to the thymidylate synthase family.
In the N-terminal section; belongs to the dihydrofolate reductase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    502
  • Mass (Da)
    56,930
  • Last updated
    2017-04-12 v1
  • Checksum
    38163E795867F40C
MGMYKVCSIYASTPNGGIGNEGKLPWKTLPRDLKHLQDITTAYGPDHSVQNVVIMGRKTYISIPKSSRPLKDRINIVLSSSVSDFGDGVIAAKSMQDAFDKLEKMKFNKIFIIGGSSVYKEAYDLGIVEKVYVTRVNKELPADTFVTSVPPIFEIVGISRTFSYNDIPFDFIIYMLKDSRATSNVCVDIDDYLLTEHEIRDFKYQFKALPNVTIRKHEEIQYLDIIADILSSGSENDDRTGVGVLSKFGYKMEFNLDESFPLLTTKKVFFKGIVEELLWFIKGDTSGKILLEKGVRIWEKNGTREFLDSVGLNERKEHDLGPIYGFQWRHFGAEYKDCDTNYTGQGIDQLMEAIDKIKNDPNSRRIIVCSWNVNDLSKMALPPCHCLFQFYVSQGRLSCIMYQRSADVGLGVPFNIASYSLLTLMIAQVCALRPGKFVHVLGNAHIYKTHITALTKQIQRIPYPFPILKLNAQVKRIEDFVPSDINLLCYTCHPTIKMDMAA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FO082872
EMBL· GenBank· DDBJ
SJK86128.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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