A0A1R1AVE4 · A0A1R1AVE4_PAELA
- ProteinUridylate kinase
- GenepyrH
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids242 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the reversible phosphorylation of UMP to UDP.
Catalytic activity
- UMP + ATP = UDP + ADP
Activity regulation
Allosterically activated by GTP. Inhibited by UTP.
Pathway
Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 12-15 | ATP (UniProtKB | ChEBI) | |||
Binding site | 54 | UMP (UniProtKB | ChEBI) | |||
Binding site | 55 | ATP (UniProtKB | ChEBI) | |||
Binding site | 59 | ATP (UniProtKB | ChEBI) | |||
Binding site | 74 | UMP (UniProtKB | ChEBI) | |||
Binding site | 135-142 | UMP (UniProtKB | ChEBI) | |||
Binding site | 163 | ATP (UniProtKB | ChEBI) | |||
Binding site | 169 | ATP (UniProtKB | ChEBI) | |||
Binding site | 172 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | UMP kinase activity | |
Biological Process | 'de novo' CTP biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | UDP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUridylate kinase
- EC number
- Short namesUK
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Paenibacillaceae > Paenibacillus
Accessions
- Primary accessionA0A1R1AVE4
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 7-216 | Aspartate/glutamate/uridylate kinase | |||
Region | 20-25 | Involved in allosteric activation by GTP | |||
Sequence similarities
Belongs to the UMP kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length242
- Mass (Da)26,133
- Last updated2017-04-12 v1
- Checksum1D38F37CA0CA88A9
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP032412 EMBL· GenBank· DDBJ | AYB43502.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MRTF01000009 EMBL· GenBank· DDBJ | OME89528.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QLYT01000024 EMBL· GenBank· DDBJ | RAR43368.1 EMBL· GenBank· DDBJ | Genomic DNA |