A0A1R1AVE4 · A0A1R1AVE4_PAELA

Function

function

Catalyzes the reversible phosphorylation of UMP to UDP.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Activity regulation

Allosterically activated by GTP. Inhibited by UTP.

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site12-15ATP (UniProtKB | ChEBI)
Binding site54UMP (UniProtKB | ChEBI)
Binding site55ATP (UniProtKB | ChEBI)
Binding site59ATP (UniProtKB | ChEBI)
Binding site74UMP (UniProtKB | ChEBI)
Binding site135-142UMP (UniProtKB | ChEBI)
Binding site163ATP (UniProtKB | ChEBI)
Binding site169ATP (UniProtKB | ChEBI)
Binding site172ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' CTP biosynthetic process
Biological Processphosphorylation
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridylate kinase
  • EC number
  • Short names
    UK
  • Alternative names
    • Uridine monophosphate kinase
      (UMP kinase
      ; UMPK
      )

Gene names

    • Name
      pyrH
    • ORF names
      BK123_24395
      , D5F53_09475
      , DP091_12720

Organism names

  • Taxonomic identifier
  • Strains
    • FSL F4-0100
    • MDMC362
    • E7593-69
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Paenibacillaceae > Paenibacillus

Accessions

  • Primary accession
    A0A1R1AVE4

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain7-216Aspartate/glutamate/uridylate kinase
Region20-25Involved in allosteric activation by GTP

Sequence similarities

Belongs to the UMP kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    242
  • Mass (Da)
    26,133
  • Last updated
    2017-04-12 v1
  • Checksum
    1D38F37CA0CA88A9
MEQPVYKRVILKVSGESLSGQNGYGIDAETISSIAEQVREVVELGVEVAIVCGGGNIWRGIAGSANGIDRATADYMGMLATVMNSLALQDALEQIDVPTRVQTSISMQQIAEPYIRRRAIRHLEKGRVVIFAAGTGNPYFSTDTTAALRAAEIEAEVILMAKNKVDGVYSADPFKDETAEKYEQLTYLDVLNKNLGVMDSTASSLCMDNNIPLIVFAITEQGNIKRVVLGEKIGTIVKGSVD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP032412
EMBL· GenBank· DDBJ
AYB43502.1
EMBL· GenBank· DDBJ
Genomic DNA
MRTF01000009
EMBL· GenBank· DDBJ
OME89528.1
EMBL· GenBank· DDBJ
Genomic DNA
QLYT01000024
EMBL· GenBank· DDBJ
RAR43368.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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