A0A1Q9MWR3 · A0A1Q9MWR3_PROA4

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site120substrate
Binding site254-256substrate
Binding site263Mn2+ (UniProtKB | ChEBI)
Binding site283Mn2+ (UniProtKB | ChEBI)
Binding site306substrate
Binding site307-312GTP (UniProtKB | ChEBI)
Active site308
Binding site325Mn2+ (UniProtKB | ChEBI)
Binding site422-424substrate
Binding site424GTP (UniProtKB | ChEBI)
Binding site455GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processoxaloacetate metabolic process
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      RBG13Loki_2061

Organism names

Accessions

  • Primary accession
    A0A1Q9MWR3

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain65-273Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain279-639Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    658
  • Mass (Da)
    73,858
  • Last updated
    2017-04-12 v1
  • MD5 Checksum
    6D34AC21DCC7676F30A35C300656525B
MGQLVHNETNFNGAKERTAWQNYSLGKNSPYKSVLNGMPIDPKILDKKNLKKLEAVENPKVMEIVEYYANLCKPAKITVITDDPKDIAFVRKKALDTKEEVPLAMKGHTIHFDGINDLARDPKSTAVLVDGDAKMSKVINTKNRTEGLKEIEGYMDGAMKGKEMIIRFFCLGPTSSRFSISALQLTDSFYVAHSEDLLYRSGYEQFKRLKTSTDFFCFVHSAGELENGVSKNVTKRRIYIDLKENRVLTINNQYAGNSLGLKKLALRLGVNKASIEGGWLAEHYFIMGIHPPGKTRVTYVAGAYPSACGKTSTAMIPGQSIIGDDIAYLRPDAKKEYALAANIEQGIFGIIQDVNPVDDPVIYEVLTSPREQIFSNVLVVDGVPYWLGMGKDLPQKGINFSGEWFEGKKDAEGKTIPPAHSNGRYTLRLKELPNVDPRSDDXXXXXXNAIFYGGRDSDTTVPVVEALNWEHGVFFGGTVESETTSAIIGAQGVRRADPMANRDFLVIPLGKYLENHRAFGASVKNAPKIFATNYFLKKDGKYLNSKVDKKVWVLWAEGRCYGENGAIETPVGFIPKYADLKALFKSIFNKDYTEKDYEAQFTIRVAKYLEKMDRMEKMYKEEGVIPDFFWEVLADQRKRLTEARAKFDVDEISPSKFT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MBAA01000117
EMBL· GenBank· DDBJ
OLS14307.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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