A0A1Q8VMV8 · A0A1Q8VMV8_9ACTO
- ProteinAspartate 1-decarboxylase
- GenepanD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids151 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
Catalytic activity
- L-aspartate + H+ = beta-alanine + CO2
Cofactor
Note: Binds 1 pyruvoyl group covalently per subunit.
Pathway
Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 28 | Schiff-base intermediate with substrate; via pyruvic acid | |||
Binding site | 60 | substrate | |||
Active site | 61 | Proton donor | |||
Binding site | 76-78 | substrate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | aspartate 1-decarboxylase activity | |
Biological Process | alanine biosynthetic process | |
Biological Process | pantothenate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAspartate 1-decarboxylase
- EC number
- Alternative names
- Cleaved into 2 chains
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Actinomycetales > Actinomycetaceae > Actinomyces
Accessions
- Primary accessionA0A1Q8VMV8
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_5041503606 | 1-27 | Aspartate 1-decarboxylase beta chain | ||
Modified residue | 28 | Pyruvic acid (Ser) | |||
Chain | PRO_5041503607 | 28-151 | Aspartate 1-decarboxylase alpha chain | ||
Post-translational modification
Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.
Keywords
- PTM
Interaction
Subunit
Heterooctamer of four alpha and four beta subunits.
Structure
Sequence
- Sequence statusComplete
- Length151
- Mass (Da)16,138
- Last updated2017-04-12 v1
- Checksum96F618C92F2CF8AB
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MSKL01000017 EMBL· GenBank· DDBJ | OLO49437.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MSKW01000014 EMBL· GenBank· DDBJ | OLO76721.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VICC01000011 EMBL· GenBank· DDBJ | TQD59006.1 EMBL· GenBank· DDBJ | Genomic DNA |