A0A1Q8JLH2 · A0A1Q8JLH2_9PSEU
- ProteinSiroheme synthase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids406 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
Catalytic activity
- NAD+ + precorrin-2 = 2 H+ + NADH + sirohydrochlorin
Pathway
Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 196 | Proton acceptor | ||||
Sequence: D | ||||||
Active site | 218 | Proton donor | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | NAD binding | |
Molecular Function | precorrin-2 dehydrogenase activity | |
Molecular Function | sirohydrochlorin ferrochelatase activity | |
Molecular Function | uroporphyrin-III C-methyltransferase activity | |
Biological Process | cobalamin biosynthetic process | |
Biological Process | methylation | |
Biological Process | siroheme biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Pseudonocardiales > Pseudonocardiaceae > Pseudonocardia
Accessions
- Primary accessionA0A1Q8JLH2
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 166-377 | Tetrapyrrole methylase | ||||
Sequence: VALVGGGPGDPELITVRGRRLLSRAQVVVADRLGPRDLMDELPPDVEVMDASKIPYGRAMAQEKINELLVENARAGRFVVRLKGGDPFVYGRGFEEVQACAAAGVPVTVVPGITSAFAAPAVAGTPVTHRGVAHEIVVVSGHVAPDDPRSLTDWTALGRMTGTIVLMMAVERLGRFADALITHGRAADTPVLIVQDGTTRIQRTVRATLETA |
Sequence similarities
Belongs to the precorrin methyltransferase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length406
- Mass (Da)42,130
- Last updated2017-04-12 v1
- ChecksumBF7E5918EE3A07D2