A0A1Q4I077 · A0A1Q4I077_9MYCO
- ProteinCytochrome c oxidase subunit 1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids586 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | oxidative phosphorylation | |
Biological Process | respiratory electron transport chain |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium
Accessions
- Primary accessionA0A1Q4I077
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 40-62 | Helical | ||||
Sequence: IGIMYTVTCFVFFFIGGLMALLM | ||||||
Transmembrane | 82-109 | Helical | ||||
Sequence: LFTMHGTIMLLLYATPVVFGFANLVLPL | ||||||
Transmembrane | 121-142 | Helical | ||||
Sequence: LNAFSFWLFLFGGLTAAAGFIV | ||||||
Transmembrane | 170-196 | Helical | ||||
Sequence: LWITGLIVAGLGTILGAVNMITTVVCM | ||||||
Transmembrane | 208-234 | Helical | ||||
Sequence: IFTWNIMVTSILILIAFPILTAALFGL | ||||||
Transmembrane | 254-278 | Helical | ||||
Sequence: LWQHLFWFFGHPEVYIIALPFFGIV | ||||||
Transmembrane | 290-311 | Helical | ||||
Sequence: VFGYTTLVYATLSIAALSVAVW | ||||||
Transmembrane | 317-339 | Helical | ||||
Sequence: ATGAVLLPFFSFMTYLIAVPTGI | ||||||
Transmembrane | 360-380 | Helical | ||||
Sequence: LFSVGFLVTFLLGGLTGVMLA | ||||||
Transmembrane | 400-418 | Helical | ||||
Sequence: YVLFGTIVFATYAGIYFWF | ||||||
Transmembrane | 430-452 | Helical | ||||
Sequence: LGKLHFWLTFIGFHTTFLVQHWL | ||||||
Transmembrane | 472-493 | Helical | ||||
Sequence: GLNIVSTIGAFILGASMFPFVW |
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 23-537 | Cytochrome oxidase subunit I profile | ||||
Sequence: PKGNLVYKLITTTDHKMIGIMYTVTCFVFFFIGGLMALLMRTELAAPGLQFLSNEQYNQLFTMHGTIMLLLYATPVVFGFANLVLPLQIGAPDVAFPRLNAFSFWLFLFGGLTAAAGFIVPGGAADFGWTAYTPLSDAVHSPGAGGDLWITGLIVAGLGTILGAVNMITTVVCMRAPGMTMFRMPIFTWNIMVTSILILIAFPILTAALFGLAADRHLGAHVYDAANGGVLLWQHLFWFFGHPEVYIIALPFFGIVTEIIPVFSRKPVFGYTTLVYATLSIAALSVAVWAHHMFATGAVLLPFFSFMTYLIAVPTGIKFFNWIGTMWKGQITFETPMLFSVGFLVTFLLGGLTGVMLASPPLDFHVTDTYFVVAHFHYVLFGTIVFATYAGIYFWFPKMTGRLLDERLGKLHFWLTFIGFHTTFLVQHWLGDMGMPRRYADYLASDGFQGLNIVSTIGAFILGASMFPFVWNVFKSWRYGEVVTVDDPWGYGNSLEWATSCPPPRHNFTELPRIR | ||||||
Region | 565-586 | Disordered | ||||
Sequence: TALESPKGFGPRTEADRSTPDQ |
Sequence similarities
Belongs to the heme-copper respiratory oxidase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length586
- Mass (Da)65,060
- Last updated2017-04-12 v1
- ChecksumEDAC04A2468FFDE1