A0A1Q4HJE4 · A0A1Q4HJE4_9MYCO
- ProteinPhosphatidylglycerol--prolipoprotein diacylglyceryl transferase
- Genelgt
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids627 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
Catalytic activity
- L-cysteinyl-[prolipoprotein] + a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) = an S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate + H+
Pathway
Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 145 | a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity | |
Biological Process | lipoprotein biosynthetic process |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylglycerol--prolipoprotein diacylglyceryl transferase
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium
Accessions
- Primary accessionA0A1Q4HJE4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 24-42 | Helical | |||
Transmembrane | 54-77 | Helical | |||
Transmembrane | 97-119 | Helical | |||
Transmembrane | 196-213 | Helical | |||
Transmembrane | 219-239 | Helical | |||
Transmembrane | 251-273 | Helical | |||
Keywords
- Cellular component
PTM/Processing
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 323-343 | Disordered | |||
Region | 372-627 | Disordered | |||
Compositional bias | 375-397 | Acidic residues | |||
Compositional bias | 410-536 | Acidic residues | |||
Compositional bias | 547-561 | Acidic residues | |||
Compositional bias | 568-592 | Acidic residues | |||
Sequence similarities
Belongs to the Lgt family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length627
- Mass (Da)65,599
- Last updated2017-04-12 v1
- MD5 Checksum420187D7547E9E6F9DA5A4C4581E5CE1
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 375-397 | Acidic residues | |||
Compositional bias | 410-536 | Acidic residues | |||
Compositional bias | 547-561 | Acidic residues | |||
Compositional bias | 568-592 | Acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MPNS01000002 EMBL· GenBank· DDBJ | OJZ67644.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PDCR01000016 EMBL· GenBank· DDBJ | PEG53941.1 EMBL· GenBank· DDBJ | Genomic DNA |