A0A1Q4HGA5 · A0A1Q4HGA5_9MYCO

Function

function

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site9substrate
Binding site9-10ATP (UniProtKB | ChEBI)
Binding site17ATP (UniProtKB | ChEBI)
Site17Transition state stabilizer
Binding site41substrate
Binding site73substrate
Binding site87substrate
Binding site88-90ATP (UniProtKB | ChEBI)
Binding site98ATP (UniProtKB | ChEBI)
Binding site122-128ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functionpantetheine-phosphate adenylyltransferase activity
Biological Processcoenzyme A biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphopantetheine adenylyltransferase
  • EC number
  • Alternative names
    • Dephospho-CoA pyrophosphorylase
    • Pantetheine-phosphate adenylyltransferase
      (PPAT
      )

Gene names

    • Name
      coaD
    • ORF names
      BRW64_09725
      , BV510_13640
      , CRI78_00660

Organism names

  • Taxonomic identifier
  • Strains
    • BM1
    • Bard
    • IP141170001
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium

Accessions

  • Primary accession
    A0A1Q4HGA5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-132Cytidyltransferase-like

Sequence similarities

Belongs to the bacterial CoaD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    158
  • Mass (Da)
    17,084
  • Last updated
    2017-04-12 v1
  • Checksum
    DC3C2F557C8ECB03
MSGAVCPGSFDPVTLGHVDIFERAAAQFDEVVVAVLVNPNKKGMFSSEERIELIRASTTHLPNLRVESGSGLVVDFVKERGLTAIVKGLRSGTDFEYELQMAQMNKHVAGVDTFFVATTPQYSFVSSSLAKEVAQLGGDVSDLLPEPVNARLKEKLGR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MPNS01000004
EMBL· GenBank· DDBJ
OJZ66525.1
EMBL· GenBank· DDBJ
Genomic DNA
MIJD01000129
EMBL· GenBank· DDBJ
OPE53796.1
EMBL· GenBank· DDBJ
Genomic DNA
PDCR01000001
EMBL· GenBank· DDBJ
PEG56402.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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