A0A1Q4HDS3 · A0A1Q4HDS3_9MYCO

Function

function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site43-50ATP (UniProtKB | ChEBI)
Active site50Proton donor
Binding site75(R)-pantoate (UniProtKB | ChEBI)
Binding site75beta-alanine (UniProtKB | ChEBI)
Binding site161-164ATP (UniProtKB | ChEBI)
Binding site167(R)-pantoate (UniProtKB | ChEBI)
Binding site190ATP (UniProtKB | ChEBI)
Binding site198-201ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionpantoate-beta-alanine ligase activity
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pantothenate synthetase
  • EC number
  • Short names
    PS
  • Alternative names
    • Pantoate--beta-alanine ligase
    • Pantoate-activating enzyme

Gene names

    • Name
      panC
    • ORF names
      BRW64_14115
      , BV510_23880
      , CRI78_03375

Organism names

  • Taxonomic identifier
  • Strains
    • BM1
    • Bard
    • IP141170001
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium

Accessions

  • Primary accession
    A0A1Q4HDS3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the pantothenate synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    311
  • Mass (Da)
    33,463
  • Last updated
    2017-04-12 v1
  • MD5 Checksum
    1FF5AC14D23AB073521D19A11A723CFE
MTERKKPTFTAGELNVYRRPADVADVTRALRGAGRRVMLVPTMGALHEGHLTLIRKARQVPGSAVVVSIFVNPLQFGAGEDLDAYPRTLDEDLAALRAEGVDIAFTPTANDMYPTGPRTTVQPGPLGEELEGASRPTHFAGMLTVVCKLLQIVAPDRAFFGEKDYQQLVLIRQMADDLNLDTRIVAVPIVREADGLAMSSRNRYLDAVQREQALAIPSALLAGVYAAGEGASAALDAARAVLDEVPDIGVDYLEVRNNWLGPAPETGRARMLVAARLGSTRLLDNIAIDIGVPSGPGPDVPFDGHELPWRN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MPNS01000006
EMBL· GenBank· DDBJ
OJZ65663.1
EMBL· GenBank· DDBJ
Genomic DNA
MIJD01000334
EMBL· GenBank· DDBJ
OPE48315.1
EMBL· GenBank· DDBJ
Genomic DNA
PDCR01000003
EMBL· GenBank· DDBJ
PEG56036.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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