A0A1Q4HDS3 · A0A1Q4HDS3_9MYCO
- ProteinPantothenate synthetase
- GenepanC
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids311 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Miscellaneous
The reaction proceeds by a bi uni uni bi ping pong mechanism.
Catalytic activity
- (R)-pantoate + beta-alanine + ATP = (R)-pantothenate + AMP + diphosphate + H+
Pathway
Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 43-50 | ATP (UniProtKB | ChEBI) | |||
Active site | 50 | Proton donor | |||
Binding site | 75 | (R)-pantoate (UniProtKB | ChEBI) | |||
Binding site | 75 | beta-alanine (UniProtKB | ChEBI) | |||
Binding site | 161-164 | ATP (UniProtKB | ChEBI) | |||
Binding site | 167 | (R)-pantoate (UniProtKB | ChEBI) | |||
Binding site | 190 | ATP (UniProtKB | ChEBI) | |||
Binding site | 198-201 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | ATP binding | |
Molecular Function | pantoate-beta-alanine ligase activity | |
Biological Process | pantothenate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePantothenate synthetase
- EC number
- Short namesPS
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium
Accessions
- Primary accessionA0A1Q4HDS3
Proteomes
Subcellular Location
Interaction
Structure
Sequence
- Sequence statusComplete
- Length311
- Mass (Da)33,463
- Last updated2017-04-12 v1
- MD5 Checksum1FF5AC14D23AB073521D19A11A723CFE
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MPNS01000006 EMBL· GenBank· DDBJ | OJZ65663.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MIJD01000334 EMBL· GenBank· DDBJ | OPE48315.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PDCR01000003 EMBL· GenBank· DDBJ | PEG56036.1 EMBL· GenBank· DDBJ | Genomic DNA |