A0A1Q2SS58 · A0A1Q2SS58_9GAMM

Function

function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site39-46ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentexcinuclease repair complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionDNA binding
Molecular Functionexcinuclease ABC activity
Biological Processnucleotide-excision repair
Biological ProcessSOS response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    UvrABC system protein B
  • Short names
    Protein UvrB
  • Alternative names
    • Excinuclease ABC subunit B

Gene names

    • Name
      uvrB

Organism names

Accessions

  • Primary accession
    A0A1Q2SS58

Subcellular Location

Keywords

Interaction

Subunit

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.

Family & Domains

Features

Showing features for domain, motif.

TypeIDPosition(s)Description
Domain26-162Helicase ATP-binding
Motif92-115Beta-hairpin
Domain430-592Helicase C-terminal
Domain623-658UVR

Domain

The beta-hairpin motif is involved in DNA binding.

Sequence similarities

Belongs to the UvrB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    664
  • Mass (Da)
    75,906
  • Last updated
    2017-04-12 v1
  • Checksum
    1204157CEEE99829
MDNRFQLISKFSPSGDQPEAIKTLVDGVNAGAKFQTLLGVTGSGKTFTLANVIQQTERSSLIMAPNKTLAAQLYSEMKEFFPHNSVEYFVSYYDYYQPEAYVPASDTYIEKDSSINEQIEQMRLSATKALLERDDVIIIASVSAIYGLGNPESYMAMLLHLSIGEIINQREILSRLSQMQYSRNDITLMRGHFRVKGEVIDIFPADSEEQAIRIEMFDEEIEQLYWFDPLTGEKLKSLQKITIYPQTHYVTPKSKILNMLDDIKVELKDRRSELLSVNKLVEEQRLTQRVHMDIEMMRELGYCTGIENYSRYLSSQNPGEPPSTLLDYLPDNALVILDESHVTVSQIGGMYKGDRARKKTLVEFGFRLPSALDNRPLRFSEFEDRVHQCILVSATPAQYELEVSSVIAEQVVRPTGLLDPEIDIRPVDTQVDDLLSEIRMRVKVNERVLVTTLTKKMSERLSDYLNDHHVKVRYLHSDIDTVERVEIIRDLRLGVFDVLVGINLLREGLDIPEVSLVAILDADKEGFLRSERSLIQTMGRAARNINGHVILYAARITKSMQKAMDETKRRRVKQQDYNLKNNITPKGIAKPIINILDTDLTSSQKKENGVQKVFTQLSPVQLAKEIKVLEKQMYSFASDLAFEHAADMRNQIKQLKDTQFKKAL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB911383
EMBL· GenBank· DDBJ
BAW82180.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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