A0A1Q2M6W4 · A0A1Q2M6W4_9GAMM

  • Protein
    Arginine biosynthesis bifunctional protein ArgJ
  • Gene
    argJ
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N2-acetylornithine and glutamate.

Miscellaneous

Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N2-acetyl-L-ornithine (cyclic): step 1/1.
Amino-acid biosynthesis; L-arginine biosynthesis; N2-acetyl-L-ornithine from L-glutamate: step 1/4.

Features

Showing features for site, binding site, active site.

Type
IDPosition(s)Description
Site110Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Site111Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole
Binding site147substrate
Binding site173substrate
Site183-184Cleavage; by autolysis
Active site184Nucleophile
Binding site184substrate
Binding site270substrate
Binding site394substrate
Binding site399substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionglutamate N-acetyltransferase activity
Molecular FunctionL-glutamate N-acetyltransferase activity
Biological Processarginine biosynthetic process
Biological Processornithine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Including 2 domains:

  • Recommended name
    Glutamate N-acetyltransferase
  • EC number
  • Alternative names
    • Ornithine acetyltransferase
      (OATase
      )
    • Ornithine transacetylase
  • Recommended name
    Amino-acid acetyltransferase
  • EC number
  • Alternative names
    • N-acetylglutamate synthase
      (AGSase
      )

Gene names

    • Name
      argJ
    • ORF names
      Mag101_13210

Organism names

  • Taxonomic identifier
  • Strain
    • GP101
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Cellvibrionales > Microbulbiferaceae > Microbulbifer

Accessions

  • Primary accession
    A0A1Q2M6W4

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_50232919721-183Arginine biosynthesis bifunctional protein ArgJ alpha chain
ChainPRO_5023291971184-399Arginine biosynthesis bifunctional protein ArgJ beta chain

Keywords

Interaction

Subunit

Heterotetramer of two alpha and two beta chains.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the ArgJ family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    399
  • Mass (Da)
    41,638
  • Last updated
    2017-04-12 v1
  • Checksum
    977AEE450AEA29A3
MAQPFPSIPGIRLAAVPAKVKDWQRDDLLLIDIAEGAAVSATFTQNAFCAAPVLVAKEHIQQGGIRALLINAGNANAATGEQGLLDANRCCAGVAEALGVSAQQVLPFSTGVIGEHLPVQNILSAIPSAAAQLRPDGWESAAAAIMTTDTRPKTASRSVTIAGEKISIVGIAKGAGMIQPNMATMLAYVATDARIPQDVLDSLVQEAVAASFNRISVDGDTSTNDACVLIASGATGPEVADTHSDAYAQLKAAIIGVHIELAQAIVKDGEGATKFVTVQVNNAASSEEALSMAFEIGESPLVKTALYASDPNWGRLVMAIGNAGATDLDTSKISVYLDNVQIVDAGGRASSYTEDAGQKVFEQAEFTISVDLQRGNVNEHIWTCDFSHEYVTINAEYRT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP019650
EMBL· GenBank· DDBJ
AQQ68485.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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