A0A1Q1PQG0 · A0A1Q1PQG0_9TELE

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Cyprinidae > 'Poropuntiinae' > Poropuntius

Accessions

  • Primary accession
    A0A1Q1PQG0

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane15-37Helical
Transmembrane57-83Helical
Transmembrane104-128Helical
Transmembrane148-171Helical
Transmembrane183-210Helical
Transmembrane243-261Helical
Transmembrane268-291Helical
Transmembrane303-327Helical
Transmembrane339-359Helical
Transmembrane379-400Helical
Transmembrane412-436Helical
Transmembrane448-473Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-511Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    516
  • Mass (Da)
    56,860
  • Last updated
    2017-04-12 v1
  • Checksum
    AD999D3B51498879
MAITRWFFSTNHKDIGTLYLVFGAWAGMVGTALSLLIRAELSQPGSLLGDDQIYNVIVTAHAFVMIFFMVMPILIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTTINMKPPAISQYQTPLFVWSVLVTAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPKVYILILPGFGIISHVVAYYSGKKEPFGYMGMVWAMMAIGLLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGSIKWETPMLWALGFIFLFTVGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAAFVHWFPLLTGYTLHSAWTKIHFAVMFIGVNLTFFPQHFLGLAGMPRRYSDYPDAYALWNTVSSIGSLISLVAVIMFLFILWEAFAAKREVLSVELTMTNVEWLHGCPPPYHTYEEPAFVQIQSN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY319984
EMBL· GenBank· DDBJ
AQM74048.1
EMBL· GenBank· DDBJ
Genomic DNA
KY319985
EMBL· GenBank· DDBJ
AQM74049.1
EMBL· GenBank· DDBJ
Genomic DNA
KY319986
EMBL· GenBank· DDBJ
AQM74050.1
EMBL· GenBank· DDBJ
Genomic DNA
KY319987
EMBL· GenBank· DDBJ
AQM74051.1
EMBL· GenBank· DDBJ
Genomic DNA
KY319988
EMBL· GenBank· DDBJ
AQM74052.1
EMBL· GenBank· DDBJ
Genomic DNA
KY319989
EMBL· GenBank· DDBJ
AQM74053.1
EMBL· GenBank· DDBJ
Genomic DNA
KY319990
EMBL· GenBank· DDBJ
AQM74054.1
EMBL· GenBank· DDBJ
Genomic DNA
KY319991
EMBL· GenBank· DDBJ
AQM74055.1
EMBL· GenBank· DDBJ
Genomic DNA
KY319992
EMBL· GenBank· DDBJ
AQM74056.1
EMBL· GenBank· DDBJ
Genomic DNA
KY319993
EMBL· GenBank· DDBJ
AQM74057.1
EMBL· GenBank· DDBJ
Genomic DNA
KY319994
EMBL· GenBank· DDBJ
AQM74058.1
EMBL· GenBank· DDBJ
Genomic DNA
KY319995
EMBL· GenBank· DDBJ
AQM74059.1
EMBL· GenBank· DDBJ
Genomic DNA
KY319996
EMBL· GenBank· DDBJ
AQM74060.1
EMBL· GenBank· DDBJ
Genomic DNA
KY319997
EMBL· GenBank· DDBJ
AQM74061.1
EMBL· GenBank· DDBJ
Genomic DNA
KY319998
EMBL· GenBank· DDBJ
AQM74062.1
EMBL· GenBank· DDBJ
Genomic DNA
KY319999
EMBL· GenBank· DDBJ
AQM74063.1
EMBL· GenBank· DDBJ
Genomic DNA
KY320000
EMBL· GenBank· DDBJ
AQM74064.1
EMBL· GenBank· DDBJ
Genomic DNA
KY320001
EMBL· GenBank· DDBJ
AQM74065.1
EMBL· GenBank· DDBJ
Genomic DNA
KY320002
EMBL· GenBank· DDBJ
AQM74066.1
EMBL· GenBank· DDBJ
Genomic DNA
KY320003
EMBL· GenBank· DDBJ
AQM74067.1
EMBL· GenBank· DDBJ
Genomic DNA
KY320004
EMBL· GenBank· DDBJ
AQM74068.1
EMBL· GenBank· DDBJ
Genomic DNA
KY320005
EMBL· GenBank· DDBJ
AQM74069.1
EMBL· GenBank· DDBJ
Genomic DNA
KY320006
EMBL· GenBank· DDBJ
AQM74070.1
EMBL· GenBank· DDBJ
Genomic DNA
KY320007
EMBL· GenBank· DDBJ
AQM74071.1
EMBL· GenBank· DDBJ
Genomic DNA
KY320008
EMBL· GenBank· DDBJ
AQM74072.1
EMBL· GenBank· DDBJ
Genomic DNA
KY320009
EMBL· GenBank· DDBJ
AQM74073.1
EMBL· GenBank· DDBJ
Genomic DNA
KY320010
EMBL· GenBank· DDBJ
AQM74074.1
EMBL· GenBank· DDBJ
Genomic DNA
KY320011
EMBL· GenBank· DDBJ
AQM74075.1
EMBL· GenBank· DDBJ
Genomic DNA
KY320012
EMBL· GenBank· DDBJ
AQM74076.1
EMBL· GenBank· DDBJ
Genomic DNA
KY320013
EMBL· GenBank· DDBJ
AQM74077.1
EMBL· GenBank· DDBJ
Genomic DNA
KY320014
EMBL· GenBank· DDBJ
AQM74078.1
EMBL· GenBank· DDBJ
Genomic DNA
KY320015
EMBL· GenBank· DDBJ
AQM74079.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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