A0A1Q1PQG0 · A0A1Q1PQG0_9TELE
- ProteinCytochrome c oxidase subunit 1
- GeneCOI
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids516 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Catalytic activity
- 4 Fe(II)-[cytochrome c] + O2 + 8 H+(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H+(out)This reaction proceeds in the forward direction.
4 RHEA-COMP:10350 + CHEBI:15379 + 8 H+ (in)CHEBI:15378= 4 RHEA-COMP:14399 + 2 CHEBI:15377 + 4 H+ (out)CHEBI:15378
Cofactor
Protein has several cofactor binding sites:
Pathway
Energy metabolism; oxidative phosphorylation.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial inner membrane | |
Cellular Component | respiratory chain complex IV | |
Molecular Function | cytochrome-c oxidase activity | |
Molecular Function | heme binding | |
Molecular Function | metal ion binding | |
Biological Process | electron transport coupled proton transport | |
Biological Process | mitochondrial electron transport, cytochrome c to oxygen |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCytochrome c oxidase subunit 1
- EC number
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Cyprinidae > 'Poropuntiinae' > Poropuntius
Accessions
- Primary accessionA0A1Q1PQG0
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 15-37 | Helical | |||
Transmembrane | 57-83 | Helical | |||
Transmembrane | 104-128 | Helical | |||
Transmembrane | 148-171 | Helical | |||
Transmembrane | 183-210 | Helical | |||
Transmembrane | 243-261 | Helical | |||
Transmembrane | 268-291 | Helical | |||
Transmembrane | 303-327 | Helical | |||
Transmembrane | 339-359 | Helical | |||
Transmembrane | 379-400 | Helical | |||
Transmembrane | 412-436 | Helical | |||
Transmembrane | 448-473 | Helical | |||
Keywords
- Cellular component
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length516
- Mass (Da)56,860
- Last updated2017-04-12 v1
- ChecksumAD999D3B51498879
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KY319984 EMBL· GenBank· DDBJ | AQM74048.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY319985 EMBL· GenBank· DDBJ | AQM74049.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY319986 EMBL· GenBank· DDBJ | AQM74050.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY319987 EMBL· GenBank· DDBJ | AQM74051.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY319988 EMBL· GenBank· DDBJ | AQM74052.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY319989 EMBL· GenBank· DDBJ | AQM74053.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY319990 EMBL· GenBank· DDBJ | AQM74054.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY319991 EMBL· GenBank· DDBJ | AQM74055.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY319992 EMBL· GenBank· DDBJ | AQM74056.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY319993 EMBL· GenBank· DDBJ | AQM74057.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY319994 EMBL· GenBank· DDBJ | AQM74058.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY319995 EMBL· GenBank· DDBJ | AQM74059.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY319996 EMBL· GenBank· DDBJ | AQM74060.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY319997 EMBL· GenBank· DDBJ | AQM74061.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY319998 EMBL· GenBank· DDBJ | AQM74062.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY319999 EMBL· GenBank· DDBJ | AQM74063.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY320000 EMBL· GenBank· DDBJ | AQM74064.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY320001 EMBL· GenBank· DDBJ | AQM74065.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY320002 EMBL· GenBank· DDBJ | AQM74066.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY320003 EMBL· GenBank· DDBJ | AQM74067.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY320004 EMBL· GenBank· DDBJ | AQM74068.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY320005 EMBL· GenBank· DDBJ | AQM74069.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY320006 EMBL· GenBank· DDBJ | AQM74070.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY320007 EMBL· GenBank· DDBJ | AQM74071.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY320008 EMBL· GenBank· DDBJ | AQM74072.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY320009 EMBL· GenBank· DDBJ | AQM74073.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY320010 EMBL· GenBank· DDBJ | AQM74074.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY320011 EMBL· GenBank· DDBJ | AQM74075.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY320012 EMBL· GenBank· DDBJ | AQM74076.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY320013 EMBL· GenBank· DDBJ | AQM74077.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY320014 EMBL· GenBank· DDBJ | AQM74078.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
KY320015 EMBL· GenBank· DDBJ | AQM74079.1 EMBL· GenBank· DDBJ | Genomic DNA |