A0A1P8D9L9 · A0A1P8D9L9_MICCB

Function

function

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.

Cofactor

Protein has several cofactor binding sites:
heme b (UniProtKB | Rhea| CHEBI:60344 )

Note: Binds 2 heme groups non-covalently.
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme groups non-covalently.

Features

Showing features for binding site.

138050100150200250300350
TypeIDPosition(s)Description
Binding site83Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site97Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site182Fe (UniProtKB | ChEBI) of heme b b562 (UniProtKB | ChEBI); axial binding residue
Binding site196Fe (UniProtKB | ChEBI) of heme b b566 (UniProtKB | ChEBI); axial binding residue
Binding site201a ubiquinone (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex III
Molecular Functionmetal ion binding
Molecular Functionubiquinol-cytochrome-c reductase activity
Biological Processmitochondrial electron transport, ubiquinol to cytochrome c

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome b

Gene names

    • Name
      cytb

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • SM2055
    • SM2056
    • SM2057
    • SM2058
    • SM2059
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Arvicolinae > Microtus

Accessions

  • Primary accession
    A0A1P8D9L9

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane30-52Helical
Transmembrane87-107Helical
Transmembrane113-133Helical
Transmembrane145-166Helical
Transmembrane178-200Helical
Transmembrane229-246Helical
Transmembrane288-307Helical
Transmembrane319-340Helical
Transmembrane346-368Helical

Keywords

Interaction

Subunit

The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-209Cytochrome b/b6 N-terminal region profile
Domain210-380Cytochrome b/b6 C-terminal region profile

Sequence similarities

Belongs to the cytochrome b family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    380
  • Mass (Da)
    42,824
  • Last updated
    2017-04-12 v1
  • MD5 Checksum
    C394B3B5372F4EE2582CBD751EC6F243
MTIIRKKHPLIKIINHSFIDLPTPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTATAFSSVAHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGIYYGSYNMMETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVLVHLLFLHETGSNNPAGLNSDADKIPFHPYYTVKDFLGVLILLMAFMILTLFFPDALGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILAAMPYLHTSKQRTLTFRPITQSIYWILVADLLILTWIGGQPVEHPFIIIGQTASIAYFTIIIILMPISGMIENNILDLD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY380748
EMBL· GenBank· DDBJ
APU53200.1
EMBL· GenBank· DDBJ
Genomic DNA
KY380754
EMBL· GenBank· DDBJ
APU53206.1
EMBL· GenBank· DDBJ
Genomic DNA
KY380755
EMBL· GenBank· DDBJ
APU53207.1
EMBL· GenBank· DDBJ
Genomic DNA
KY380798
EMBL· GenBank· DDBJ
APU53250.1
EMBL· GenBank· DDBJ
Genomic DNA
KY380799
EMBL· GenBank· DDBJ
APU53251.1
EMBL· GenBank· DDBJ
Genomic DNA
KY380800
EMBL· GenBank· DDBJ
APU53252.1
EMBL· GenBank· DDBJ
Genomic DNA
KY380801
EMBL· GenBank· DDBJ
APU53253.1
EMBL· GenBank· DDBJ
Genomic DNA
KY380802
EMBL· GenBank· DDBJ
APU53254.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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