A0A1P8ASW4 · A0A1P8ASW4_ARATH
- Proteinmitogen-activated protein kinase kinase kinase
- GeneMAP3KA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids525 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | protein kinase activity |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namemitogen-activated protein kinase kinase kinase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionA0A1P8ASW4
Proteomes
Organism-specific databases
Genome annotation databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-202 | Disordered | ||||
Sequence: MPTWWGRKSCKNKDDNHRGIISTDRDIKSSAVVVDPPLTPTRGGTPRCSREFAGASSAFSGFDSDSTEKKGHPLPRPLLSPVSIHHQDHVSGSTSGSTSVSSVSSSGSADDQSQLVASRGRGDVKFNVAAAPRSPERVSPKAATITTRPTSPRHQRLSGVVSLESSTGRNDDGRSSSECHPLPRPPTSPTSPSAVHGSRIGG | ||||||
Compositional bias | 8-24 | Basic and acidic residues | ||||
Sequence: KSCKNKDDNHRGIISTD | ||||||
Compositional bias | 86-115 | Polar residues | ||||
Sequence: HQDHVSGSTSGSTSVSSVSSSGSADDQSQL | ||||||
Compositional bias | 140-170 | Polar residues | ||||
Sequence: PKAATITTRPTSPRHQRLSGVVSLESSTGRN | ||||||
Domain | 214-470 | Protein kinase | ||||
Sequence: WKKGKFLGSGTFGQVYLGFNSEKGKMCAIKEVKVISDDQTSKECLKQLNQEINLLNQLCHPNIVQYYGSELSEETLSVYLEYVSGGSIHKLLKDYGSFTEPVIQNYTRQILAGLAYLHGRNTVHRDIKGANILVDPNGEIKLADFGMAKHVTAFSTMLSFKGSPYWMAPEVVMSQNGYTHAVDIWSLGCTILEMATSKPPWSQFEGVAAIFKIGNSKDTPEIPDHLSNDAKNFIRLCLQRNPTVRPTASQLLEHPFL | ||||||
Region | 478-525 | Disordered | ||||
Sequence: STSLPKDFPPRSYDGNFSLQPTREPYPGRLSHDNYAKQPLSRTIKSPR |
Sequence similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length525
- Mass (Da)57,259
- Last updated2017-04-12 v1
- Checksum1827CC3FA2D57687
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F4HRJ4 | M3K3A_ARATH | MAPKKK3 | 609 | ||
A0A1P8AT18 | A0A1P8AT18_ARATH | MAP3KA | 524 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 8-24 | Basic and acidic residues | ||||
Sequence: KSCKNKDDNHRGIISTD | ||||||
Compositional bias | 86-115 | Polar residues | ||||
Sequence: HQDHVSGSTSGSTSVSSVSSSGSADDQSQL | ||||||
Compositional bias | 140-170 | Polar residues | ||||
Sequence: PKAATITTRPTSPRHQRLSGVVSLESSTGRN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP002684 EMBL· GenBank· DDBJ | ANM59751.1 EMBL· GenBank· DDBJ | Genomic DNA |