A0A1P7Y0C9 · SQS8_PANGI
- ProteinSqualene synthase 8
- GeneSS8
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids391 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Component of the triterpene saponins (e.g. ginsenosides or panaxosides) and phytosterols biosynthetic pathways (PubMed:27746309, PubMed:29378087).
Catalyzes the biosynthesis of squalene (By similarity).
Catalyzes the biosynthesis of squalene (By similarity).
Catalytic activity
- 2 (2E,6E)-farnesyl diphosphate + H+ + NADH = 2 diphosphate + NAD+ + squaleneThis reaction proceeds in the forward direction.
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Pathway
Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | farnesyl-diphosphate farnesyltransferase activity | |
Molecular Function | farnesyltranstransferase activity | |
Molecular Function | squalene synthase activity | |
Biological Process | farnesyl diphosphate metabolic process | |
Biological Process | isoprenoid biosynthetic process | |
Biological Process | response to jasmonic acid | |
Biological Process | response to molecule of fungal origin |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSqualene synthase 8
- EC number
- Short namesPgSS8 ; SQS 8
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > asterids > campanulids > Apiales > Araliaceae > Panax
Accessions
- Primary accessionA0A1P7Y0C9
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000446955 | 1-391 | Squalene synthase 8 | |||
Sequence: MGSLGAILKHPDDFYPLLKLKIAARHAEKQIPSEPHWAFCYSMLHKVSRSFGLVIQQLGPQLRDAVCIFYLVLRALDTVEDDTSISTEVKVPIVMAFHCHIYDNDWHFSCGTKEYKVLMDEFHHVSNAFLDLGSSYKEAIEDITMRMGAGMAKFICKEVETIDDYDEYCHYVAGLVGLGLSKLFHASGAEDLATDSLSNSMGLFLQKTNIIRDYLEDINEIPKSRMFWPRQIWSKYVDKLEDLKYEENSAKAVQCLNDMVTDALVHAEDCLKYMSDLRGPAIFRFCAIPQIMAIGTLALCFNNTQVFRGVVKMRRGLTAKVIDQTKTMSDVYGAFFDFSCLLKSKVDNNDPNATKTLSRLEAIQKTCKESGTLSKRFCVFDFPLETIFYRV |
Structure
Sequence
- Sequence statusComplete
- Length391
- Mass (Da)44,481
- Last updated2017-04-12 v1
- Checksum0F7F3A563FD87AB1