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A0A1P6C218 · A0A1P6C218_BRUMA

Function

function

Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity. Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects.

Catalytic activity

  • (2E)-geranial + NADPH + O2 + H+ = (1E)-2,6-dimethylhepta-1,5-dien-1-yl formate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • octan-3-one + NADPH + O2 + H+ = pentyl propanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • octan-3-one + NADPH + O2 + H+ = ethyl hexanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • sulcatone + NADPH + O2 + H+ = 4-methylpent-3-en-1-yl acetate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • NADPH + O2 + H+ = H2O2 + NADP+
    This reaction proceeds in the forward direction.
    EC:1.6.3.1 (UniProtKB | ENZYME | Rhea)
  • heptan-2-one + NADPH + O2 + H+ = pentyl acetate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • heptan-4-one + NADPH + O2 + H+ = propyl butanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • hexan-3-one + NADPH + O2 + H+ = propyl propanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.
  • hexan-3-one + NADPH + O2 + H+ = ethyl butanoate + NADP+ + H2O
    This reaction proceeds in the forward direction.

Cofactor

FAD (UniProtKB | Rhea| CHEBI:57692 )

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionhypotaurine dehydrogenase activity
Molecular FunctionN,N-dimethylaniline monooxygenase activity
Molecular FunctionNAD(P)H oxidase H2O2-forming activity
Molecular FunctionNADP binding
Biological Processlipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Flavin-containing monooxygenase
  • EC number

Gene names

    • Name
      Bm4677
    • ORF names
      BM_Bm4677

Organism names

  • Taxonomic identifier
  • Strain
    • FR3
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Spirurina > Spiruromorpha > Filarioidea > Onchocercidae > Brugia

Accessions

  • Primary accession
    A0A1P6C218

Proteomes

Subcellular Location

Keywords

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the FMO family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    528
  • Mass (Da)
    60,529
  • Last updated
    2017-03-15 v1
  • MD5 Checksum
    13324391D68FA4C9FD77603927A0CC75
MPERICVVGAGASGLTATKTCLENGLQVVCFEKSCDIGGLWRYKSQPCPGEGTVMKNTTINTSKEMTAFSDFVPPPEMPNFMSHIQMLAYFRSYANHFHLLQHIRLSHEVTRIERDEKYEETGRWNVTYRIINDNTTQTEKFEGILLCCGHHTIPYWPKPFPGQDKFRGEIIHSHDYREPFSYIDKTVVLIGIGNSSGDIAVDLSRISKEVYISTRNGTWVIGRTWDKGEPIDLVFVSRYVQTVTKIMPSWLVNKSYEKKLNLQFDHGRYGLKPKHHALAQHATISDELPSRIACGTVIIKPNVARFTEHDVIFEDGTAVCNVDAVIFGTGYSFQFPIVEDGNLIPVTDNKVDLYLHIFPPQLSPKNTLAVIGLIQPVGSIMPVSEMQSRFYCEVFAGHCKLPAIDKMKKDVERRRVQIEKRFLKSRRHTLEVDYATYMDELAKMVGVKPNLLKYWFTDPRLAYILLFEGLAPYQFRLNGPYAWVGARDALLGMARRTFENSRTRQTTETMKSKPINKFLYYLNMMKF

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LN856924
EMBL· GenBank· DDBJ
CDP94155.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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