A0A1P6BJ19 · A0A1P6BJ19_BRUMA
- ProteinSerine/threonine-protein kinase receptor
- GeneBma-daf-1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids541 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- ATP + L-threonyl-[receptor-protein] = ADP + H+ + O-phospho-L-threonyl-[receptor-protein]
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Features
Showing features for binding site, active site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | activin receptor complex | |
Molecular Function | activin binding | |
Molecular Function | activin receptor activity, type I | |
Molecular Function | ATP binding | |
Molecular Function | metal ion binding | |
Biological Process | cellular response to growth factor stimulus | |
Biological Process | dauer entry | |
Biological Process | defense response to Gram-negative bacterium | |
Biological Process | detection of bacterium | |
Biological Process | determination of adult lifespan | |
Biological Process | larval feeding behavior | |
Biological Process | negative regulation of dauer larval development | |
Biological Process | nervous system development | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | regulation of nematode pharyngeal pumping |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSerine/threonine-protein kinase receptor
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Spirurina > Spiruromorpha > Filarioidea > Onchocercidae > Brugia
Accessions
- Primary accessionA0A1P6BJ19
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 150-175 | Helical | ||||
Sequence: FIHSVVIFLIGIAVFVFSIFLVFAWI |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MQTLSSFVFFLFVIVTRA | ||||||
Chain | PRO_5010812671 | 19-541 | Serine/threonine-protein kinase receptor | |||
Sequence: IKDNSDPGYVILKFMERFQANLKEPINLSEELICNCSYSGCGEEITRFLGNNYTGLCRSTSGICHKRLLPDRSVILSCLSKDASPDLHCRAKQPMNDGSIMQCCQNYSFCNGALNLNPVNDYILFQDNNISFIHSVVIFLIGIAVFVFSIFLVFAWINKPLKRWLFYWTHHRSGEEHSEVTGEEKLLMNSTDALGHLSDLLYNLDDSATTGSGSGFPLLAQRTIARQIELQKEIGQGRFGEVWLGYWKGDEVAVKIFSSRDERSWNREVEIFQTNLLRHPNLLRFIASDNKDTGTSTQLWLITEYHEHGSLYDYLSANPVSESVMLQMIRSIAVGLSFLHNEIPGKPAIAHRDLKSKNILVKSDLTCVIADLGLAVRYMNGEINVPDNSKCGTVRYLAPEILEDNFSINHFETYKTADMYAMGLMIWEIMWRCGSQEESRSFELPYFDCVGRDPTMEEMKLCVCIQKRRPTVQEHWIDDKVMRGVLQIMQECWTESPVCRLTAMNVRKAVDRHAASLGWKVRS | ||||||
Disulfide bond | 107↔121 | |||||
Sequence: CRAKQPMNDGSIMQC |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 213-245 | GS | ||||
Sequence: GHLSDLLYNLDDSATTGSGSGFPLLAQRTIARQ | ||||||
Domain | 246-534 | Protein kinase | ||||
Sequence: IELQKEIGQGRFGEVWLGYWKGDEVAVKIFSSRDERSWNREVEIFQTNLLRHPNLLRFIASDNKDTGTSTQLWLITEYHEHGSLYDYLSANPVSESVMLQMIRSIAVGLSFLHNEIPGKPAIAHRDLKSKNILVKSDLTCVIADLGLAVRYMNGEINVPDNSKCGTVRYLAPEILEDNFSINHFETYKTADMYAMGLMIWEIMWRCGSQEESRSFELPYFDCVGRDPTMEEMKLCVCIQKRRPTVQEHWIDDKVMRGVLQIMQECWTESPVCRLTAMNVRKAVDRHAAS |
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length541
- Mass (Da)61,785
- Last updated2017-03-15 v1
- ChecksumBB420A403C411590
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A5S6P909 | A0A5S6P909_BRUMA | Bma-daf-1 | 65 | ||
A0A1P6BJ00 | A0A1P6BJ00_BRUMA | Bma-daf-1 | 372 | ||
A0A1P6BJ39 | A0A1P6BJ39_BRUMA | Bma-daf-1 | 539 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LN857010 EMBL· GenBank· DDBJ | CDQ00094.1 EMBL· GenBank· DDBJ | Genomic DNA |