A0A1N7E5U3 · A0A1N7E5U3_9EURY
- ProteinNAD kinase
- GenenadK
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids599 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Catalytic activity
- NAD+ + ATP = ADP + NADP+ + H+
Cofactor
Protein has several cofactor binding sites:
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 65 | Proton acceptor | |||
Binding site | 65-66 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 134-135 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 150 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 398 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 415 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 417 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 418 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | |||
Binding site | 535 | Mg2+ 1 (UniProtKB | ChEBI); catalytic | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | inositol monophosphate 1-phosphatase activity | |
Molecular Function | metal ion binding | |
Molecular Function | NAD+ kinase activity | |
Biological Process | inositol metabolic process | |
Biological Process | NAD metabolic process | |
Biological Process | NADP biosynthetic process | |
Biological Process | phosphatidylinositol phosphate biosynthetic process | |
Biological Process | phosphorylation | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNAD kinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Natrialbaceae > Natronorubrum
Accessions
- Primary accessionA0A1N7E5U3
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 287-331 | Disordered | |||
Compositional bias | 309-323 | Basic and acidic residues | |||
Sequence similarities
Belongs to the NAD kinase family.
Belongs to the inositol monophosphatase superfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length599
- Mass (Da)64,372
- Last updated2017-03-15 v1
- Checksum03954C56762E08D1
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 309-323 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP019327 EMBL· GenBank· DDBJ | APX96382.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FTNP01000003 EMBL· GenBank· DDBJ | SIR83513.1 EMBL· GenBank· DDBJ | Genomic DNA |