A0A1N7E5U3 · A0A1N7E5U3_9EURY

Function

function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site65Proton acceptor
Binding site65-66NAD+ (UniProtKB | ChEBI)
Binding site134-135NAD+ (UniProtKB | ChEBI)
Binding site150NAD+ (UniProtKB | ChEBI)
Binding site398Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site415Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site417Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site418Mg2+ 1 (UniProtKB | ChEBI); catalytic
Binding site535Mg2+ 1 (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functioninositol monophosphate 1-phosphatase activity
Molecular Functionmetal ion binding
Molecular FunctionNAD+ kinase activity
Biological Processinositol metabolic process
Biological ProcessNAD metabolic process
Biological ProcessNADP biosynthetic process
Biological Processphosphatidylinositol phosphate biosynthetic process
Biological Processphosphorylation
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD kinase
  • EC number
  • Alternative names
    • ATP-dependent NAD kinase

Gene names

    • Name
      nadK
    • ORF names
      BB347_06985
      , SAMN05421809_2482

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • JX313
    • CGMCC 1.8909
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Natrialbaceae > Natronorubrum

Accessions

  • Primary accession
    A0A1N7E5U3

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region287-331Disordered
Compositional bias309-323Basic and acidic residues

Sequence similarities

Belongs to the NAD kinase family.
Belongs to the inositol monophosphatase superfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    599
  • Mass (Da)
    64,372
  • Last updated
    2017-03-15 v1
  • Checksum
    03954C56762E08D1
MQGRRLATTDEIIAIVSPDSDEPLETLTAWTEQSGIELTTVDVGDDIGDVYDESRATLGVTLGGDGTFLEGIKTFAPRKIPQLGVNTGTLAFLARVEPEDLEDALEEVLRGRAAVDSRQQVYVNAPGVEATGINDVMIQQVPPDDPIDRKVTRLDVYADDEYVGEFEGTGLAVSTPTGSTGISLSANGPVHYPVNNHTLQLVPLHTHKLGVRPIVVSPETELRIISRGGANLLVDGGRAQTLLEVGDEVVVTGADTLAHVVRTSYDDHFFTAITKKLGWDVRDADVPRDKKREAPAATSPPIDATDSSRTSIRARHDSAAGDGSRSDEAAGTVERALTVATEAAQAAGEPLRELHGQVESIDHKTDKSDIATEADHQADRIISTVIDNEFPEHGLFSEEGTRDRSGDSNYTWVVDPLDGTGNFAHGNPNYSISVALIDHDRPVLGVVYVPETDELFTGIAGQGAWRDGDPIETTDRDRLDESMLISGYDPDGSFLSHFYQESRGVRRLGSAALNLCYLASASADAVWEHDTYPWDIAAGLVIAREAGATITDQSGERFEFDFDTEARAALLGSNGSLHPALLEHLGDGLQSSSRSQSSR

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias309-323Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP019327
EMBL· GenBank· DDBJ
APX96382.1
EMBL· GenBank· DDBJ
Genomic DNA
FTNP01000003
EMBL· GenBank· DDBJ
SIR83513.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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