A0A1N6ZGQ8 · A0A1N6ZGQ8_9EURY

  • Protein
    Coenzyme A biosynthesis bifunctional protein CoaBC
  • Gene
    coaBC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site287CTP (UniProtKB | ChEBI)
Binding site296CTP (UniProtKB | ChEBI)
Binding site329CTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentphosphopantothenoylcysteine decarboxylase complex
Molecular FunctionFMN binding
Molecular Functionmetal ion binding
Molecular Functionphosphopantothenate--cysteine ligase activity
Molecular Functionphosphopantothenoylcysteine decarboxylase activity
Biological Processcoenzyme A biosynthetic process
Biological Processpantothenate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Coenzyme A biosynthesis bifunctional protein CoaBC
  • Alternative names
    • DNA/pantothenate metabolism flavoprotein
    • Phosphopantothenoylcysteine synthetase/decarboxylase
      (PPCS-PPCDC
      )

Including 2 domains:

  • Recommended name
    Phosphopantothenoylcysteine decarboxylase
  • EC number
  • Short names
    PPC decarboxylase
    ; PPC-DC
  • Alternative names
    • CoaC
  • Recommended name
    Phosphopantothenate--cysteine ligase
  • EC number
  • Alternative names
    • CoaB
    • Phosphopantothenoylcysteine synthetase
      (PPC synthetase
      ; PPC-S
      )

Gene names

    • Name
      coaBC
    • ORF names
      BB347_01310
      , SAMN05421809_0797

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • JX313
    • CGMCC 1.8909
  • Taxonomic lineage
    Archaea > Euryarchaeota > Stenosarchaea group > Halobacteria > Halobacteriales > Natrialbaceae > Natronorubrum

Accessions

  • Primary accession
    A0A1N6ZGQ8

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-183Phosphopantothenoylcysteine decarboxylase
Domain6-168Flavoprotein
Domain179-367DNA/pantothenate metabolism flavoprotein C-terminal
Region184-409Phosphopantothenate--cysteine ligase

Sequence similarities

In the C-terminal section; belongs to the PPC synthetase family.
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    409
  • Mass (Da)
    42,315
  • Last updated
    2017-03-15 v1
  • Checksum
    D6066D7F82A57F59
MLEGVNVALGVTGSIAAVKTVELAHELRRQGASVRAVMSGSATGIIHPWAVEFATDNDVVTEITGSVEHVELCGYDGWADVFVIAPATANTVGKIAGAVDDTPVTTTATTALGADTPVVIAPAMHEPMYDHPGVLEAIDTVSAWGVEFVDPRVEEGKAKIASEDAIVTDIARAAGDRPLEGDHVVVTSGATGEAIDPVRVLTNRSSGKMGREVAKACYVRGADVTLVHGLVGPRSITSDGAVAQTNPDGTVSYATLRSVESADAMLEATREACTDADTLVSVAAIGDYTVDSSAEKIRSGQDLSLSLEPTPKLIDEIRDDHPELPIVGFKTETSGDEAAMIAQARETLERAELAFVVANDASVMGAEQTNALLVHDADAARFSGSKAGLAGEIADSIATLLESELTDTA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP019327
EMBL· GenBank· DDBJ
APX95356.1
EMBL· GenBank· DDBJ
Genomic DNA
FTNP01000001
EMBL· GenBank· DDBJ
SIR25941.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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