A0A1M7KAD1 · A0A1M7KAD1_CHRCU

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site7-12substrate
Active site68Proton acceptor
Binding site68Mg2+ (UniProtKB | ChEBI)
Binding site69substrate
Binding site147-150substrate
Binding site170substrate
Binding site175-176substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      NCTC13533_03442

Organism names

  • Taxonomic identifier
  • Strain
    • NCTC13533
  • Taxonomic lineage
    Bacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Weeksellaceae > Chryseobacterium group > Chryseobacterium

Accessions

  • Primary accession
    A0A1M7KAD1
  • Secondary accessions
    • A0A376E7Q2

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    191
  • Mass (Da)
    21,646
  • Last updated
    2017-03-15 v1
  • Checksum
    65F9A55A765A7C01
MELLVATHNIHKKEEIQQILGNDFTVKSLTDYNIHEEIVEDGDSFNANALIKAKYCFEKTGIPSLGDDSGLAVEALDGRPGIFSARYAGDHDFAKNMEKVLGELEGEDNRKAYFITVLCYYDENGARYFEGRVHGNILTENKGHKGFGYDPIFVPQGYDRTFAEMNPDDKNKISHRKQALDLFLDFLKVKD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
UFVQ01000003
EMBL· GenBank· DDBJ
STD03349.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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