A0A1M2TV29 · A0A1M2TV29_ECOLX

  • Protein
    2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase
  • Gene
    mhpB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Pathway

Aromatic compound metabolism; 3-phenylpropanoate degradation.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site115Proton donor
Active site179Proton acceptor

GO annotations

AspectTerm
Molecular Function3-carboxyethylcatechol 2,3-dioxygenase activity
Molecular Functionferrous iron binding
Biological Process3-phenylpropionate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase
  • EC number
  • Alternative names
    • 3-carboxyethylcatechol 2,3-dioxygenase

Gene names

    • Name
      mhpB
    • ORF names
      HVW43_10460
      , TUM18780_33240

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • RHB10-C12
    • TUM18780
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    A0A1M2TV29

Proteomes

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-306Extradiol ring-cleavage dioxygenase class III enzyme subunit B

Sequence similarities

Belongs to the LigB/MhpB extradiol dioxygenase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    314
  • Mass (Da)
    34,197
  • Last updated
    2017-03-15 v1
  • Checksum
    EC8ECE710C3FFC8D
MHAYLHCLSHSPLVGYVDPAQEVLDEVDGVIASARERIAAFSPELVVLFAPDHYNGFFYDVMPPFCLGVGATAIGDFGSAAGELPVPVELAEACAHAVMKSGIDLAVSYCMQVDHGFAQPLEFLLGGLDKVPVLPVFINGVATPLPGFQRTRMLGEAIGRFTSTLNKRVLFLGSGGLSHQPPVPELAKADAHMRDRLLGSGKDLPASERELRQQRVISAAEKFVEDQRTLHPLNPIWDNQFMTLLEQGRIQELDAVSNEELSAIAGKSTHEIKTWVAAFAAISAFGNWRSEGRYYRPIPEWIAGFGSLSARTEN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP023197
EMBL· GenBank· DDBJ
BCG38162.1
EMBL· GenBank· DDBJ
Genomic DNA
CP057906
EMBL· GenBank· DDBJ
QMO40705.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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