A0A1L9WQK0 · VRCC_ASPA1
- ProteinABC-type transporter vrcC
- GenevrcC
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1413 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
ABC-type transporter; part of the gene cluster that mediates the biosynthesis of the sesterterpene variecolin (PubMed:38261827).
VrcC is probably involved in the secretion of variecolin (Probable)
VrcC is probably involved in the secretion of variecolin (Probable)
Biotechnology
Variecolin and its derivatives produced by employing P450 monooxygenases from other fungal terpenoid pathways exhibit anticancer activity, thus, the skeleton of variecolin could be considered a privileged scaffold for developing anticancer agents.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | ABC-type transporter activity | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameABC-type transporter vrcC
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Circumdati
Accessions
- Primary accessionA0A1L9WQK0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 476-496 | Helical | ||||
Sequence: VTISSLIGNVITALVIASIFY | ||||||
Transmembrane | 510-530 | Helical | ||||
Sequence: ALLFFACLINALGCGLEMLTL | ||||||
Transmembrane | 564-584 | Helical | ||||
Sequence: VLNAILSLVQALPFCAVVLLG | ||||||
Transmembrane | 683-703 | Helical | ||||
Sequence: IGIILAFMVVLGAIYLVATDF | ||||||
Transmembrane | 1105-1125 | Helical | ||||
Sequence: IYIYSKAILCVLPALFVGFSL | ||||||
Transmembrane | 1142-1162 | Helical | ||||
Sequence: IFLLLIQFGQLIQQIMPHFVT | ||||||
Transmembrane | 1191-1211 | Helical | ||||
Sequence: LFWNSLMSILMFLCWYYPIGM | ||||||
Transmembrane | 1230-1250 | Helical | ||||
Sequence: LLIWTFLLFSSTFAHFMIAAL | ||||||
Transmembrane | 1266-1286 | Helical | ||||
Sequence: LCLLFCGVLATPAQLPGFWIF | ||||||
Transmembrane | 1290-1310 | Helical | ||||
Sequence: VSPFTYLVSGMLAVGIADTTV | ||||||
Transmembrane | 1378-1398 | Helical | ||||
Sequence: FGLMWVFIFTNIVAACLLYWW |
Keywords
- Cellular component
Phenotypes & Variants
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000460552 | 1-1413 | ABC-type transporter vrcC | |||
Sequence: MADDHKVESGLNTHVEKRAEEVHQLARQFTEQSTFSTAGQNPFAAEPGSVLDPIGNNFDALAWCKAMLHVHTEDEKAHPLRTLGIAFNNLYVHGFGSDTDYQKSVGNVWFEALALARKALGTQNQRRIQILQNLEGTVEAGEMLVVLGPPGSGCSTFLKTIAGETDGFHIDKESSINYQGVSAKKMAHEFRGEAIYAAEVDVHFPKLTVGDTLYFAARARAPRHIPGGVDVAQYASHKRDVIMAILGISHTKNTIVGNDFIRGVSGGERKRVSIAEACLSSAPLQCWDNSTRGLDSANAIEFCKALRMQADINGATVCVSLYQAPQAAYHYFDKVLVLYEGRQIFFGRTDAAKQYFLDMGFACPERQTDADFLTSMTSHIERVVQPGYEGCVPRTPDEFAARWRGSHQRARVLQDVENYNTKFTLNGEFLGKFRHSRRAQQARVQRVSSPYTLSYAQQVNLCLWRGYQRLKADPSVTISSLIGNVITALVIASIFYNLQPNTSTFFQRGALLFFACLINALGCGLEMLTLYAQRGIVEKHARYALYHPSAEAISSMIMDLPFKVLNAILSLVQALPFCAVVLLGLYSYTGFAIPTGYMLGWARWIAYINPINYGFESLLINEFHDRDFQCVAIVPSGPSYMDLHSRNQVCSTVGSVPGQAFVNGDAYIQSAYDYNVSHKWRNIGIILAFMVVLGAIYLVATDFITEKKSKGEILVFPRGHGALKSGKPDDFEGGSDRNASQEKSKSDRDDLTVIESQTAIFQWQDVCFDIKIGKESRRILDHVDGWVKPGTLTALMGVSGAGKTTLLDVLATRTTLGVISGEMLVDGKPRDESFQRKTGYAQQQDLHLSTATVREALEFSALLRQPAHVPRREKINYVTEVIKLLDMADYADAVIGVPGEGLNVEQRKRLTIGVELAARPALLLFLDEPTSGLDSQTSWAILDLLNKLRKNGQAILCTIHQPSAMLFQRFDRLLFLQAGGQTVYFGDIGQNSQILIDYFVRNGGPPCPPAANPAEWMLDVIGAAPGSHTDIDWFETWRNSPEYAQVQAHLSSLKLEHAQQNPLARVSPGTEREDRASYREFAAPFCAQLREVQIRVFQQFWRSPIYIYSKAILCVLPALFVGFSLFNTPNTIQGLQNQMFSIFLLLIQFGQLIQQIMPHFVTQRALYEVRERPSKTYSWTVFMLSNIGVELFWNSLMSILMFLCWYYPIGMYRNAEPSDTVHLRGAQMWLLIWTFLLFSSTFAHFMIAALDAAENAGNLGSFLLLLCLLFCGVLATPAQLPGFWIFMYRVSPFTYLVSGMLAVGIADTTVTCADNEYLRFDPVNDTTCGQYLAPYIAQAGGYLHDETATAACRFCPVADTNAYLRGVGASYADVWRNFGLMWVFIFTNIVAACLLYWWTRVPRVKKPVVAPQA | ||||||
Glycosylation | 289 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 501 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 675 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 738 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 1324 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 108-365 | ABC transporter 1 | ||||
Sequence: VWFEALALARKALGTQNQRRIQILQNLEGTVEAGEMLVVLGPPGSGCSTFLKTIAGETDGFHIDKESSINYQGVSAKKMAHEFRGEAIYAAEVDVHFPKLTVGDTLYFAARARAPRHIPGGVDVAQYASHKRDVIMAILGISHTKNTIVGNDFIRGVSGGERKRVSIAEACLSSAPLQCWDNSTRGLDSANAIEFCKALRMQADINGATVCVSLYQAPQAAYHYFDKVLVLYEGRQIFFGRTDAAKQYFLDMGFACPE | ||||||
Region | 725-748 | Disordered | ||||
Sequence: SGKPDDFEGGSDRNASQEKSKSDR | ||||||
Domain | 761-1003 | ABC transporter 2 | ||||
Sequence: FQWQDVCFDIKIGKESRRILDHVDGWVKPGTLTALMGVSGAGKTTLLDVLATRTTLGVISGEMLVDGKPRDESFQRKTGYAQQQDLHLSTATVREALEFSALLRQPAHVPRREKINYVTEVIKLLDMADYADAVIGVPGEGLNVEQRKRLTIGVELAARPALLLFLDEPTSGLDSQTSWAILDLLNKLRKNGQAILCTIHQPSAMLFQRFDRLLFLQAGGQTVYFGDIGQNSQILIDYFVRNG |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,413
- Mass (Da)157,474
- Last updated2017-03-15 v1
- Checksum213C57E93168C3C5
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KV878980 EMBL· GenBank· DDBJ | OJJ98431.1 EMBL· GenBank· DDBJ | Genomic DNA |