A0A1L9WQK0 · VRCC_ASPA1

Function

function

ABC-type transporter; part of the gene cluster that mediates the biosynthesis of the sesterterpene variecolin (PubMed:38261827).
VrcC is probably involved in the secretion of variecolin (Probable)

Biotechnology

Variecolin and its derivatives produced by employing P450 monooxygenases from other fungal terpenoid pathways exhibit anticancer activity, thus, the skeleton of variecolin could be considered a privileged scaffold for developing anticancer agents.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular FunctionABC-type transporter activity
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    ABC-type transporter vrcC
  • Alternative names
    • Variecolin biosynthesis cluster protein C

Gene names

    • Name
      vrcC
    • ORF names
      ASPACDRAFT_61942

Organism names

Accessions

  • Primary accession
    A0A1L9WQK0

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane476-496Helical
Transmembrane510-530Helical
Transmembrane564-584Helical
Transmembrane683-703Helical
Transmembrane1105-1125Helical
Transmembrane1142-1162Helical
Transmembrane1191-1211Helical
Transmembrane1230-1250Helical
Transmembrane1266-1286Helical
Transmembrane1290-1310Helical
Transmembrane1378-1398Helical

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00004605521-1413ABC-type transporter vrcC
Glycosylation289N-linked (GlcNAc...) asparagine
Glycosylation501N-linked (GlcNAc...) asparagine
Glycosylation675N-linked (GlcNAc...) asparagine
Glycosylation738N-linked (GlcNAc...) asparagine
Glycosylation1324N-linked (GlcNAc...) asparagine

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain108-365ABC transporter 1
Region725-748Disordered
Domain761-1003ABC transporter 2

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,413
  • Mass (Da)
    157,474
  • Last updated
    2017-03-15 v1
  • Checksum
    213C57E93168C3C5
MADDHKVESGLNTHVEKRAEEVHQLARQFTEQSTFSTAGQNPFAAEPGSVLDPIGNNFDALAWCKAMLHVHTEDEKAHPLRTLGIAFNNLYVHGFGSDTDYQKSVGNVWFEALALARKALGTQNQRRIQILQNLEGTVEAGEMLVVLGPPGSGCSTFLKTIAGETDGFHIDKESSINYQGVSAKKMAHEFRGEAIYAAEVDVHFPKLTVGDTLYFAARARAPRHIPGGVDVAQYASHKRDVIMAILGISHTKNTIVGNDFIRGVSGGERKRVSIAEACLSSAPLQCWDNSTRGLDSANAIEFCKALRMQADINGATVCVSLYQAPQAAYHYFDKVLVLYEGRQIFFGRTDAAKQYFLDMGFACPERQTDADFLTSMTSHIERVVQPGYEGCVPRTPDEFAARWRGSHQRARVLQDVENYNTKFTLNGEFLGKFRHSRRAQQARVQRVSSPYTLSYAQQVNLCLWRGYQRLKADPSVTISSLIGNVITALVIASIFYNLQPNTSTFFQRGALLFFACLINALGCGLEMLTLYAQRGIVEKHARYALYHPSAEAISSMIMDLPFKVLNAILSLVQALPFCAVVLLGLYSYTGFAIPTGYMLGWARWIAYINPINYGFESLLINEFHDRDFQCVAIVPSGPSYMDLHSRNQVCSTVGSVPGQAFVNGDAYIQSAYDYNVSHKWRNIGIILAFMVVLGAIYLVATDFITEKKSKGEILVFPRGHGALKSGKPDDFEGGSDRNASQEKSKSDRDDLTVIESQTAIFQWQDVCFDIKIGKESRRILDHVDGWVKPGTLTALMGVSGAGKTTLLDVLATRTTLGVISGEMLVDGKPRDESFQRKTGYAQQQDLHLSTATVREALEFSALLRQPAHVPRREKINYVTEVIKLLDMADYADAVIGVPGEGLNVEQRKRLTIGVELAARPALLLFLDEPTSGLDSQTSWAILDLLNKLRKNGQAILCTIHQPSAMLFQRFDRLLFLQAGGQTVYFGDIGQNSQILIDYFVRNGGPPCPPAANPAEWMLDVIGAAPGSHTDIDWFETWRNSPEYAQVQAHLSSLKLEHAQQNPLARVSPGTEREDRASYREFAAPFCAQLREVQIRVFQQFWRSPIYIYSKAILCVLPALFVGFSLFNTPNTIQGLQNQMFSIFLLLIQFGQLIQQIMPHFVTQRALYEVRERPSKTYSWTVFMLSNIGVELFWNSLMSILMFLCWYYPIGMYRNAEPSDTVHLRGAQMWLLIWTFLLFSSTFAHFMIAALDAAENAGNLGSFLLLLCLLFCGVLATPAQLPGFWIFMYRVSPFTYLVSGMLAVGIADTTVTCADNEYLRFDPVNDTTCGQYLAPYIAQAGGYLHDETATAACRFCPVADTNAYLRGVGASYADVWRNFGLMWVFIFTNIVAACLLYWWTRVPRVKKPVVAPQA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KV878980
EMBL· GenBank· DDBJ
OJJ98431.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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