A0A1L9V3I6 · A0A1L9V3I6_ASPGL
- ProteinATP-dependent RNA helicase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids643 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.
RNA helicase.
Catalytic activity
- ATP + H2O = ADP + H+ + phosphate
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleolus | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Biological Process | rRNA processing |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent RNA helicase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Aspergillus
Accessions
- Primary accessionA0A1L9V3I6
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for domain, motif, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 14-42 | DEAD-box RNA helicase Q | ||||
Sequence: WDGVNPPLSEWVLEAVSSMGFTRMTPVQA | ||||||
Motif | 14-42 | Q motif | ||||
Sequence: WDGVNPPLSEWVLEAVSSMGFTRMTPVQA | ||||||
Domain | 45-248 | Helicase ATP-binding | ||||
Sequence: IPLFMAHKDVVVEAVTGSGKTLSFLIPVVEKLLRVEEPIKKHHVGAIIISPTRELASQIYKVLLSLLEFHPASAAAINPSEDDASRKKQSSSTYKVVPQLLLGGATSPAEDLSNFLKRSPNLLVSTPGRLLELLSSPHVHCPQSSFEMLVLDEADRLLDLGFKNDLQNILRRLPKQRRTGLFSASVSEAVDQIVRVGLRNPVKV | ||||||
Domain | 282-436 | Helicase C-terminal | ||||
Sequence: ALKKILSSVQPTPQKTIFFVSTCTGVDYLAAILPSILGNEYSLIPLHGKHPATVRQKNFNAYVNSQTPAILLTTDVASRGLDIPSVDLVVQLDPPADPKTFIHRCGRAGRAGRRGISVVLLHPGREEDYVSFLEVRKTPVTAFPYPIDITDEDAA | ||||||
Region | 530-643 | Disordered | ||||
Sequence: RKEALAEYQNGTAEDNQQSNKRPASESVAWSDKLDNKNKKAKRKDQKKAKQDHTKWERMTEEEKQKVLETETMLAEVKKKNDEERRLRREAKKAETGGKGAAGDGVEEEFQGFD | ||||||
Compositional bias | 539-555 | Polar residues | ||||
Sequence: NGTAEDNQQSNKRPASE | ||||||
Compositional bias | 579-626 | Basic and acidic residues | ||||
Sequence: KQDHTKWERMTEEEKQKVLETETMLAEVKKKNDEERRLRREAKKAETG |
Domain
The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.
Sequence similarities
Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length643
- Mass (Da)71,374
- Last updated2017-03-15 v1
- Checksum2FEE1D5BF5891A46
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 539-555 | Polar residues | ||||
Sequence: NGTAEDNQQSNKRPASE | ||||||
Compositional bias | 579-626 | Basic and acidic residues | ||||
Sequence: KQDHTKWERMTEEEKQKVLETETMLAEVKKKNDEERRLRREAKKAETG |
Keywords
- Technical term