A0A1L9PHG6 · A0A1L9PHG6_ASPVE
- ProteinATP-dependent DNA helicase CHL1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids988 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G2/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.
Catalytic activity
- Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | large ribosomal subunit | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA helicase activity | |
Molecular Function | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | |
Molecular Function | iron-sulfur cluster binding | |
Molecular Function | isomerase activity | |
Molecular Function | metal ion binding | |
Molecular Function | structural constituent of ribosome | |
Biological Process | establishment of sister chromatid cohesion | |
Biological Process | nucleobase-containing compound metabolic process | |
Biological Process | translation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent DNA helicase CHL1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Nidulantes
Accessions
- Primary accessionA0A1L9PHG6
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 5-405 | Helicase ATP-binding | |||
Region | 99-168 | Disordered | |||
Compositional bias | 152-168 | Polar residues | |||
Region | 846-877 | Disordered | |||
Compositional bias | 858-874 | Basic residues | |||
Sequence similarities
Belongs to the universal ribosomal protein uL15 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length988
- Mass (Da)111,042
- Last updated2017-03-15 v1
- ChecksumD869664757EE1ACC
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 152-168 | Polar residues | |||
Compositional bias | 858-874 | Basic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KV878127 EMBL· GenBank· DDBJ | OJJ00970.1 EMBL· GenBank· DDBJ | Genomic DNA |