A0A1L9PHG6 · A0A1L9PHG6_ASPVE

Function

function

ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G2/M. May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres. Has a specific role in chromosome segregation during meiosis II.

Catalytic activity

  • ATP + H2O = ADP + phosphate + H+
    EC:5.6.2.3 (UniProtKB | ENZYME | Rhea)
  • Couples ATP hydrolysis with the unwinding of duplex DNA at the replication fork by translocating in the 5'-3' direction. This creates two antiparallel DNA single strands (ssDNA). The leading ssDNA polymer is the template for DNA polymerase III holoenzyme which synthesizes a continuous strand.
    EC:5.6.2.3 (UniProtKB | ENZYME | Rhea)

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

GO annotations

AspectTerm
Cellular Componentlarge ribosomal subunit
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA helicase activity
Molecular Functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Molecular Functioniron-sulfur cluster binding
Molecular Functionisomerase activity
Molecular Functionmetal ion binding
Molecular Functionstructural constituent of ribosome
Biological Processestablishment of sister chromatid cohesion
Biological Processnucleobase-containing compound metabolic process
Biological Processtranslation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent DNA helicase CHL1
  • EC number
  • Alternative names
    • ATP-dependent DNA helicase chl1
    • Chromosome loss protein 1
    • DNA 5'-3' helicase CHL1

Gene names

    • ORF names
      ASPVEDRAFT_127473

Organism names

  • Taxonomic identifier
  • Strain
    • CBS 583.65
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Nidulantes

Accessions

  • Primary accession
    A0A1L9PHG6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain5-405Helicase ATP-binding
Region99-168Disordered
Compositional bias152-168Polar residues
Region846-877Disordered
Compositional bias858-874Basic residues

Sequence similarities

Belongs to the universal ribosomal protein uL15 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    988
  • Mass (Da)
    111,042
  • Last updated
    2017-03-15 v1
  • Checksum
    D869664757EE1ACC
MELSAAEKFHHPYSPYDIQLQFMQSLYTCLEEGKVAVFESPTGKFTPDMWLLDVASRSQTQIIPRNHDDDEPEWMMEFAKRETTRAIAEKRKEFERRLAKVRREEEQQKTTLNNPDAPRKRQKTGNALPNGDGIDDDSQFALDDYDSETDGPSPSLKESTASNGLSSSTVELLERLKGRGSKVQSEEGDGTDDIKIFYCSRTHSQLMQFANELRRVTLPSSVPEELKQVFTEEELEERIRHLSLGSRKNLCINPKVASLGDSTAINERCLELQQPNTTEQQRCSFLPSKEDDMATLSFRDHALSTVKDIEDLGKLGKKMNICPYYASRPVASQSEVAREALNISIKDQIIVIDEAHNLMDAISNIHSVTITLAQLQTSIFQLTTYARKFKTRLKGKNRSYVAQVIRLISSIADHLQSILNSNQPNEGSVLPSDLMSGKGVDQINPHKLSRYLQESKLARKVDGYVDFSQNKADQRIKIKAAVPVLFHIQSFLLPLMNVSAEGRLFYTKSQGDIQLDYMLLDPTNHFREIVENARAVILAGGTMSPMSDYLSHLFSYVPRDRLDTFSYGHVIPAENLTAHNLALGVQGSQFDFTYDGRNSEEMIYDLGLTIAKICHVVPDGVVAFFPSYDYLSQVLNRWKKPIPGETGQSFYQLIEKEKPIIYESREMETTTDDLLRHYANTIENGKGALLLSVVGGKLSEGINFSDKLGRGVLIVGLPFPNIRSPVWQAKIKHIEQKAYQNQSSGSEESRRSSAKAAGGDFYENACMRAVNQCIGRAIRHRNDYAAIILIDKRYGRSKIQSKLPGWIQQSLKKDSANLTAGTPIASPSPTLVEHSTLDKMPTRLTKTRKSRGHVSAGYGRIGKHRKHPGGRGMAGGQHHHRTNLDKYHPGYFGKVGMRYFHKTQQQFWKPTINLDKLWSLVPAEQREAYVSGKKTDTAPVIDLLSLGYSKVLGKGRLPEVPIVVRARYVSRDAEQKIKDAGGVIELVA

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias152-168Polar residues
Compositional bias858-874Basic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KV878127
EMBL· GenBank· DDBJ
OJJ00970.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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