A0A1L9P9M6 · A0A1L9P9M6_ASPVE

Function

function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.

Catalytic activity

  • S-methyl-5'-thioadenosine + phosphate = S-methyl-5-thio-alpha-D-ribose 1-phosphate + adenine
    EC:2.4.2.28 (UniProtKB | ENZYME | Rhea)

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.
Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site515phosphate (UniProtKB | ChEBI)
Binding site561-562phosphate (UniProtKB | ChEBI)
Binding site594-595phosphate (UniProtKB | ChEBI)
Site678Important for substrate specificity
Binding site696substrate
Binding site697phosphate (UniProtKB | ChEBI)
Binding site720-722substrate
Site733Important for substrate specificity

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular FunctionNADP binding
Molecular Functionphosphogluconate dehydrogenase (decarboxylating) activity
Molecular FunctionS-methyl-5-thioadenosine phosphorylase activity
Biological ProcessD-gluconate catabolic process
Biological ProcessL-methionine salvage from methylthioadenosine
Biological Processpentose-phosphate shunt, oxidative branch
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-methyl-5'-thioadenosine phosphorylase
  • EC number
  • Alternative names
    • 5'-methylthioadenosine phosphorylase
      (MTA phosphorylase
      ; MTAP
      ; MTAPase
      )

Gene names

    • ORF names
      ASPVEDRAFT_49977

Organism names

  • Taxonomic identifier
  • Strain
    • CBS 583.65
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Nidulantes

Accessions

  • Primary accession
    A0A1L9P9M6

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Nucleus

Keywords

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain197-5366-phosphogluconate dehydrogenase C-terminal

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family.
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    804
  • Mass (Da)
    88,137
  • Last updated
    2017-03-15 v1
  • Checksum
    FFFDD7BCEE6EE4FB
MPSQQEIVQKFKRIGIVGSGNMGSMMAFAFSELGLDVSIWDVKHENVDQLLESSKHTNFKNGGRIEGFYDIGKFTKSLEGQGERKIFLFSITHGDPADSVLKTIKGDLQKGDIILDGGNENYRRTERRQKECQEIGVSWIGLGVSGGYQSARRGPSLSPGGDKEALDLVMPLLELYSAKDSKTGLPCVTRIGPGGSGHFVKMVHNGIEGGMLSAVAEAWSILYYGREIGYEEIADIFAEWNSKGELRNNFLLEIGADLLRVKKTPKGDGKGQGVGDNGYVLDDVLDKVVQDDDNTEGTPYWSIMESAARHVSAPTLATAHYMRISSGNRAERLEVAKKLKIPTPTPIRGMKNFEAFREQLRRAVYASFLASFCQGLEMIARASEDEGWNIDLGKCLQIWRAGCIIRSEGIADILQPILSNNKELTNMKYIDKVAAELQRTYSSLKEITIAAIDSDHYLPAISATLEYVKYEAGLTLPTKFMEAQMDFFGAHGYNLPGVPGEDPGPPVRIAVIGGTGLRELPGFTQAASLNISTPWGNPSSPITILHHTVKDKTVAVAFLSRHGSHHQIAPHEVPARANIAALRSIGVRTIIAFSAVGSLQEEIKPRDFVVPDQVIDRTKGIRPFTFFEGGVVGHVPFGDPFDEGVAKVVRACGHSLEGEGVTLHDRGTLVCMEGPQFSTRAESKLYRSWGGSVINMSALPEAKLAREAEIAYQMICMSTDYDCWHESTEDVTVEMVMGNMKANAVNAKHFVTAVLDELAAEHNSDLVQAKQYAGSVKFGISTPQTHWSPEASERINWLFPGYFQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KV878126
EMBL· GenBank· DDBJ
OJI98185.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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