A0A1L8I8R1 · A0A1L8I8R1_9BACI

Function

function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site30-37ATP (UniProtKB | ChEBI)
Active site37Proton donor
Binding site61(R)-pantoate (UniProtKB | ChEBI)
Binding site61beta-alanine (UniProtKB | ChEBI)
Binding site148-151ATP (UniProtKB | ChEBI)
Binding site154(R)-pantoate (UniProtKB | ChEBI)
Binding site177ATP (UniProtKB | ChEBI)
Binding site185-188ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionpantoate-beta-alanine ligase activity
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pantothenate synthetase
  • EC number
  • Short names
    PS
  • Alternative names
    • Pantoate--beta-alanine ligase
    • Pantoate-activating enzyme

Gene names

    • Name
      panC
    • ORF names
      A6D91_06920

Organism names

Accessions

  • Primary accession
    A0A1L8I8R1

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the pantothenate synthetase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    298
  • Mass (Da)
    33,268
  • Last updated
    2017-03-15 v1
  • Checksum
    B9FC641CE81DFA3F
MEVITTISQLRRRLAGERAAGKCIGLVPTMGYLHDGHLSLIRRARQECDVVVMSLFVNPLQFGANEDFDRYPRDLERDRALAAEAGVDVLFHPAVEEMYPQKPSTTVRVHEALTGRLCGRSRPGHFDGVATVVSKLFHIVEPHRAYFGQKDAQQLAIIQRMVEDLNFPVQIIGCPTVREPDGLAMSSRNVYLSPEERKIAPLLYRALCHGEAMIRNGETDPEAVVTQVRQQIAQAPQFRIDYVELVSFPQLQPLETIRGTVLLAVAAWLGQTRLIDNVIIDITPQGLDEPGTDEEGEP

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LWLU01000120
EMBL· GenBank· DDBJ
OJF18171.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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