A0A1L8HJA3 · A0A1L8HJA3_XENLA

Function

function

Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation.

Catalytic activity

  • 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
    This reaction proceeds in the forward direction.
  • 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
    This reaction proceeds in the forward direction.
  • a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphate
    This reaction proceeds in the forward direction.
    EC:3.1.3.95 (UniProtKB | ENZYME | Rhea)
  • a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
    This reaction proceeds in the forward direction.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site258-261substrate
Binding site283-284substrate
Active site345Phosphocysteine intermediate
Binding site345-351substrate

GO annotations

AspectTerm
Cellular Componentearly endosome membrane
Molecular Functionphosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
Molecular Functionphosphatidylinositol-3-phosphate phosphatase activity
Biological Processphosphatidylinositol dephosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
  • EC number
  • Alternative names
    • Myotubularin-related protein 2
    • Phosphatidylinositol-3-phosphate phosphatase

Gene names

    • Name
      mtmr2.L

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    A0A1L8HJA3

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Early endosome membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Proteomic databases

Expression

Gene expression databases

    • 108708743Expressed in oocyte and 19 other cell types or tissues

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain133-508Myotubularin phosphatase
Domain314-361Tyrosine specific protein phosphatases

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    570
  • Mass (Da)
    65,873
  • Last updated
    2017-03-15 v1
  • Checksum
    443A03494AE876B9
MEELLLLPGESVKDIAKDVTYICPFSGAYRGSFTVTSYRLYFRSLERDRRLILDAPLGIISRIEKIGGAASRGENPNGIEIVCKDMRNIRFAYKQDLLTRKSVFENLMKFSFPLNYGLPLFAFEYKEVFPENGWKVYDPIQEYRRQGIPNESWRISRVNERYDLCDTYPASLVVPANISDHELRKISAFRAQDRIPVLSWIHPESQAAITRCSQPLPGVNGKRSKEDEKYLQSIMDANAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESQRKLKEISYPSIQEANWLSNLESTHWLEHIKLILSGALRIADKVESGKTSVVVHCSDGWDRTPQLTSLAMIMLDGYYRTIRGFEVLVEKEWVSFGHRFYQRIGHGDKNHADADRSPVFLQFIDCVWQMTRQFPHAFEFNEHFLLTILDHLYSCLFGTFLCNCELQRLKEGVVEESVSLWSFINNQLEDFTNPLYVNYSSHVLYPVTSTRNLELWAGYYIRWNPRTRPQEAIRSQYKVLLAKRAELQKRLEDLQREISNRSTSSSDRGSSPQPVTSVQTVV

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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