A0A1L8HJA3 · A0A1L8HJA3_XENLA
- ProteinPhosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
- Genemtmr2.L
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids570 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation.
Catalytic activity
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1-D-myo-inositol-3-phosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphateThis reaction proceeds in the forward direction.
- 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-3,5-bisphosphate) + H2O = 1,2-dioctanoyl-sn-glycero-3-phospho-(1D-myo-inositol-5-phosphate) + phosphateThis reaction proceeds in the forward direction.
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphateThis reaction proceeds in the forward direction.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 258-261 | substrate | ||||
Sequence: NKAK | ||||||
Binding site | 283-284 | substrate | ||||
Sequence: NI | ||||||
Active site | 345 | Phosphocysteine intermediate | ||||
Sequence: C | ||||||
Binding site | 345-351 | substrate | ||||
Sequence: CSDGWDR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Molecular Function | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity | |
Molecular Function | phosphatidylinositol-3-phosphate phosphatase activity | |
Biological Process | phosphatidylinositol dephosphorylation |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus
Accessions
- Primary accessionA0A1L8HJA3
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Early endosome membrane ; Peripheral membrane protein
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 133-508 | Myotubularin phosphatase | ||||
Sequence: GWKVYDPIQEYRRQGIPNESWRISRVNERYDLCDTYPASLVVPANISDHELRKISAFRAQDRIPVLSWIHPESQAAITRCSQPLPGVNGKRSKEDEKYLQSIMDANAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESQRKLKEISYPSIQEANWLSNLESTHWLEHIKLILSGALRIADKVESGKTSVVVHCSDGWDRTPQLTSLAMIMLDGYYRTIRGFEVLVEKEWVSFGHRFYQRIGHGDKNHADADRSPVFLQFIDCVWQMTRQFPHAFEFNEHFLLTILDHLYSCLFGTFLCNCELQRLKEGVVEESVSLWSFINNQLEDFTNPLYVNYSSHVLYPVTSTRNLELWAGYY | ||||||
Domain | 314-361 | Tyrosine specific protein phosphatases | ||||
Sequence: THWLEHIKLILSGALRIADKVESGKTSVVVHCSDGWDRTPQLTSLAMI |
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length570
- Mass (Da)65,873
- Last updated2017-03-15 v1
- Checksum443A03494AE876B9
Keywords
- Technical term