A0A1L8GJS2 · A0A1L8GJS2_XENLA
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- Geneplcb3.L
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1210 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 1D-myo-inositol 1-phosphate + a 1,2-diacyl-sn-glycerol + H+This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | calcium ion binding | |
Molecular Function | calmodulin binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | lipid catabolic process | |
Biological Process | phosphatidylinositol-mediated signaling | |
Biological Process | release of sequestered calcium ion into cytosol |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus
Accessions
- Primary accessionA0A1L8GJS2
Proteomes
PTM/Processing
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 474-573 | Disordered | ||||
Sequence: AVKGPEGSVKRRVSEQTSNTYSDSSSVCESSATGLPPSESADVSLTLSNGDEKIEEKPPKYTEPRKSIDHDAYSEEEEEEEPSDPKKSDEGTASSEVNAT | ||||||
Compositional bias | 484-520 | Polar residues | ||||
Sequence: RRVSEQTSNTYSDSSSVCESSATGLPPSESADVSLTL | ||||||
Compositional bias | 522-545 | Basic and acidic residues | ||||
Sequence: NGDEKIEEKPPKYTEPRKSIDHDA | ||||||
Coiled coil | 1105-1147 | |||||
Sequence: IRRLEEAQKRRQEKLQTAHQETLQRIKDEEPKLQAQLDEACQA | ||||||
Region | 1163-1210 | Disordered | ||||
Sequence: DGWVGSGSGPPSSSHSSPPSITRSWGSESGEKDSLHSPGDSSDEATRL | ||||||
Compositional bias | 1168-1190 | Polar residues | ||||
Sequence: SGSGPPSSSHSSPPSITRSWGSE | ||||||
Compositional bias | 1191-1210 | Basic and acidic residues | ||||
Sequence: SGEKDSLHSPGDSSDEATRL |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,210
- Mass (Da)138,653
- Last updated2017-03-15 v1
- ChecksumBAA36804AD17AA23
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8J1MTE4 | A0A8J1MTE4_XENLA | plcb3.L | 1189 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 484-520 | Polar residues | ||||
Sequence: RRVSEQTSNTYSDSSSVCESSATGLPPSESADVSLTL | ||||||
Compositional bias | 522-545 | Basic and acidic residues | ||||
Sequence: NGDEKIEEKPPKYTEPRKSIDHDA | ||||||
Compositional bias | 1168-1190 | Polar residues | ||||
Sequence: SGSGPPSSSHSSPPSITRSWGSE | ||||||
Compositional bias | 1191-1210 | Basic and acidic residues | ||||
Sequence: SGEKDSLHSPGDSSDEATRL |
Keywords
- Technical term