A0A1L8EBR8 · A0A1L8EBR8_HAEIR

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site9-14ITP (UniProtKB | ChEBI)
Binding site39Mg2+ (UniProtKB | ChEBI)
Binding site51ITP (UniProtKB | ChEBI)
Binding site67Mg2+ (UniProtKB | ChEBI)
Binding site67-68ITP (UniProtKB | ChEBI)
Binding site143-146ITP (UniProtKB | ChEBI)
Binding site166ITP (UniProtKB | ChEBI)
Binding site171-172ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular FunctionXTP diphosphatase activity
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Muscoidea > Muscidae > Haematobia

Accessions

  • Primary accession
    A0A1L8EBR8

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    188
  • Mass (Da)
    21,199
  • Last updated
    2017-03-15 v1
  • Checksum
    9E3567B052E4FD43
MSRPITFVTGNAKKLEELVAILGPSFPRQVVSKKIDLPELQGEIDEIAIKKCKEAARQVDGPVLVEDTCLCFNALQNLPGPYIKWFLEKLQPEGLHKLLTGWEDKSAKAICTLAFSEGKDSEPMLFQGITEGTIVEPRGPRDFGWDPIFQPKGYTVTYAEMPKEEKNKISHRFRALDALQQHFSPEKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GFDG01002621
EMBL· GenBank· DDBJ
JAV16178.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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