A0A1L7VZE7 · GUDIS_FUSPR

Function

function

Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) to yield the bicyclic sesquiterpene guaia-6,1014-diene via a 1,10-cyclization, which requires the abstraction of the pyrophosphate from FPP to yield the (E,E)-germacradienyl cation. The only accepted substrate is farnesyl diphosphate (FPP).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 3 Mg2+ ions per subunit.

Pathway

Secondary metabolite biosynthesis; terpenoid biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site134Mg2+ 1 (UniProtKB | ChEBI)
Binding site139Mg2+ 1 (UniProtKB | ChEBI)
Binding site139Mg2+ 2 (UniProtKB | ChEBI)
Binding site242substrate
Binding site288Mg2+ 3 (UniProtKB | ChEBI)
Binding site292Mg2+ 3 (UniProtKB | ChEBI)
Binding site295substrate
Binding site296Mg2+ 3 (UniProtKB | ChEBI)
Binding site375-376substrate

GO annotations

AspectTerm
Molecular Functionlyase activity
Molecular Functionmetal ion binding
Biological Processterpenoid biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    (1R,4R,5S)-(-)-guaia-6,10(14)-diene synthase
  • EC number
  • Alternative names
    • Sesquiterpene cyclase
    • Terpene synthase
    • Type I terpene cyclase

Gene names

    • ORF names
      FPRO_15464

Organism names

Accessions

  • Primary accession
    A0A1L7VZE7

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004433191-401(1R,4R,5S)---guaia-6,1014-diene synthase

Family & Domains

Features

Showing features for region, motif.

Type
IDPosition(s)Description
Region1-21Disordered
Motif134-138DDXXD motif

Domain

The Asp-Asp-Xaa-Xaa-Asp (DDXXD) motif is important for the catalytic activity, presumably through binding to Mg2+.

Sequence similarities

Belongs to the terpene synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    401
  • Mass (Da)
    45,857
  • Last updated
    2017-03-15 v1
  • Checksum
    F454D54E9DDBBB5B
MVKFDSGSESEMTNGDDLHINSKHEVKSRMANGNGVHNVPDHDQFQDRAEMEVLILPDLFSSLMSVPARENPHYASVKADADEWISSVINADAKWASRNKRVDFTYLASIWAPDCSAFALRTSADWNSWAFLFDDQFDEGHLSNDLDGAINEIARTREIMEGTAPRYTADSEHPIRYVFQTLCDRVKQSPEGFYAGKPSSERFYRRWMWAHELYWEGLVAQVRTNVEGRSFTRGPEEYLAMRRGSLGAYPALVNNEWAYGIDLPEEVADHPLVFEIMVIMSDQILLVNDILSYEKDLRLGVDHNMVRLLKAKGLSTQQAINEVGVMINNCYRRYYRALSELPCFGEEADRALLGYLEVEKNHALGSLLWSYKTGRYFKSKEDGARVRKTRELLIPKKMAAL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FJOF01000009
EMBL· GenBank· DDBJ
CZR45361.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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