A0A1L7U2E9 · FPY2_FUSMA

Function

function

UDP-glycosyltransferase; part of the gene cluster that mediates the biosynthesis of the gamma-pyrones fusapyrone (FPY) and deoxyfusapyrone (dFPY) (Ref.2). FPY is an undecaketide and thus likely synthesized by the polyketide synthase FPY1 from acetyl-CoA functioning as starter unit and the addition of 10 malonyl-CoA extender units by successive Claisen-condensations. Next to this, FPY shares some rare features: C-glycosylated 4-deoxyglucose at C-3, a gem-dimethyl group at C-13, and an alpha-beta to beta-gamma double bond shift at C-20. During FPY biosynthesis mono-C-methyl groups are transferred to the tetra-, penta-, hexa- and heptaketide, while two C-methyl groups are transferred to the nonaketide, suggesting that the CMet domain is programmed to selectively catalyze two successive C-alpha-methylation reactions of the nonaketide, while other alpha-carbons are non- or mono-methylated only. While the origin of the 4'-deoxyglucose moiety remains opaque, its transfer to C-3 is most likely mediated by the C-glycosyltransferase FPY2. Next to this, the hydroxyl group present at C-33 and discriminating between FPY and dFPY, is likely to be installed by the cytochrome P450 monooxygenase FPY7. No putative function can be predicted for the remaining genes FPY3-FPY6 (Probable).

Pathway

Secondary metabolite biosynthesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular FunctionUDP-glycosyltransferase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-glycosyltransferase FPY2
  • EC number
  • Alternative names
    • Fusapyrone biosynthesis cluster protein 2

Gene names

    • Name
      FPY2
    • ORF names
      FMAN_00007

Organism names

Accessions

  • Primary accession
    A0A1L7U2E9

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane517-537Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-20
ChainPRO_000045817621-546UDP-glycosyltransferase FPY2

Expression

Induction

Expression is induced in the presence of 6mM glutamine.

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 28 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    546
  • Mass (Da)
    62,050
  • Last updated
    2017-03-15 v1
  • Checksum
    907A7458E2F50B97
MSLPKAQILVVVTVGGSTNSAPILEICSILAARGHTIDFATLSGRQKLVDNYPFVKKVHIVGPAISAEEDEKHYILFSRWNWNTARGKRDIVKGKMAFDAFWPFTYRGLKEVITTTKPDFIFSDFHVEAALDVCNEFRLPHAVMWPQMPWLMMPQKYIPGQPGMQQRCLTSEHASIYDRLFEMTFLLRSAPFFLHWIFWTKAMRRKEGVAPRPRHSKPDYLVFMNNFYGMETPRDTPPLVHPVGPILADSYPALDGDIKSFVETHQKIALVAFGTHVILDDGKIFKIIDGLADAISSGVIDGVVWALSARSRGQLDTSIRVPSLHLSHLTIDQLFKNQDQAWHFATWVPQRSVLEHDSTIIFVTHAGPSSVNESIFHGVPMVAMGIFGDQMVTTLRLERSGVAVRLDKETFDAASLTTAIRTILLFDKESFQRNVKRMKRIAMVGSRKKHFAANVIEEHLYDWDGRFENSILDLKACSNRKRGFLQASNSKDMYPRGKELRPMHLQTPDVRMSWIKLNNIDVALLFFILLGIISWITRAAANMVRL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FCQH01000013
EMBL· GenBank· DDBJ
CVL02473.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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