A0A1L7P0A7 · A0A1L7P0A7_9ACTN
- ProteinModular polyketide synthase
- Genenmd3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids6723 (go to sequence)
- Protein existencePredicted
- Annotation score2/5
Function
Cofactor
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 2520 | Proton acceptor; for dehydratase activity | ||||
Sequence: H | ||||||
Active site | 2687 | Proton donor; for dehydratase activity | ||||
Sequence: D | ||||||
Active site | 5811 | Proton acceptor; for dehydratase activity | ||||
Sequence: H | ||||||
Active site | 5980 | Proton donor; for dehydratase activity | ||||
Sequence: D |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | 3-oxoacyl-[acyl-carrier-protein] synthase activity | |
Molecular Function | fatty acid synthase activity | |
Molecular Function | phosphopantetheine binding | |
Biological Process | DIM/DIP cell wall layer assembly | |
Biological Process | fatty acid biosynthetic process | |
Biological Process | macrolide biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionA0A1L7P0A7
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for coiled coil, domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 5-32 | |||||
Sequence: NEKLVDALRASLKETERLRRQNQQLTDA | ||||||
Domain | 34-460 | Ketosynthase family 3 (KS3) | ||||
Sequence: REPIAIVGMSCRFPGGVGSPEDLWQLVAGGQDAISGFPADRGWDMEALYDPDPERAGTFYARGGGFLYDADQFDPGFFGISPREALAMDPQQRLLLETSWEAFERAGIDPATMRGSRTGVFVGASTQAYGAGGYDLPEGVEGHLLTGTAASVASGRLSYTLGLEGPAATIDTACSSSSVALHLAVQALRQSECSLALAAGVTVLSSPDVFVEFSRQRGLSADGRCKSFAAAADGTGWSEGVGVLLVERLSDARRNGHQVLAVVRGSAVNQDGASNGLTAPNGPSQRRVIRQALESARLTPADVDAVEAHGTGTTLGDPIEAQALLATYGQDRPEGRPLWLGSLKSNIGHTQNVAGIGGVIKMVMAMRHGVLPQTLHVDEPTPHVDWSAGEVSLLTESRPWPETGRPRRAGVSSFGVSGTNVHTIIEQ | ||||||
Domain | 1493-1568 | Carrier | ||||
Sequence: RVLLDLVRTHVAGVLGHADVAEVSAERAFREIGFDSLTAVELRNGLNAATELRLPATLIYDYPNPVALADHLFTEL | ||||||
Domain | 1589-2016 | Ketosynthase family 3 (KS3) | ||||
Sequence: DEPIAIVAMSCRFPGGVRTPEELWQLLMSGTDAISGMPTDRGWDLEALYHPDPDQPGTSYARDGGFLDDAADFDPGFFGISPREALAMDPQQRLLLETSWEAFERAGIDPATVRGSAAGVFVGTNGQDYLSVLLSGEQDGIDGHVGTGNAASVISGRLAYTFGLEGPALTIDTACSSSLVALHTAVQALRAGECSMALAGGVTVMSTPGAFIEFSRQRGLAQDGRVKAFAAGADGTGWGEGVGMLLVERLSDARRNGHPVLAVVRGTAVNQDGASNGLTAPNGPSQQRVIRAALANAGLSATEVDVVEAHGTGTALGDPIEAQALLATYGQERDADRPLRLGSVKSNLGHTQAAAGVAGVMKIVLAMRHGVLPRTLHVDEPSPHVDWSAGDIELLAENQPWPETGQPRRAGVSSFGFSGTNAHAVLEQ | ||||||
Region | 2488-2613 | N-terminal hotdog fold | ||||
Sequence: HPLLAATAELPEVDGMLFTGRLALATHPWLAEHTILDTVLLPGTALVELAVRAGDQVGCDHLEELTLEVPLALPEQGGVQLRLAVGAADDAGRRSLTLHSRQEGLSAEEPWTRHASGVLSPGGRPE | ||||||
Domain | 2488-2765 | PKS/mFAS DH | ||||
Sequence: HPLLAATAELPEVDGMLFTGRLALATHPWLAEHTILDTVLLPGTALVELAVRAGDQVGCDHLEELTLEVPLALPEQGGVQLRLAVGAADDAGRRSLTLHSRQEGLSAEEPWTRHASGVLSPGGRPEASFELSVWPPADATEIDLDGRYEGLRDIGFAYGPVFQGLRRAWQRDGEIFAEVTLPEDAAEEAGRFGLHPALLDSALHAVGLEGLGNTDGQGRLPFAWSGVSLYASGAAALRVRLAPAGGDGVRLEIADTAGVPVAAVEALRLRPVSAEQVR | ||||||
Region | 2626-2765 | C-terminal hotdog fold | ||||
Sequence: ATEIDLDGRYEGLRDIGFAYGPVFQGLRRAWQRDGEIFAEVTLPEDAAEEAGRFGLHPALLDSALHAVGLEGLGNTDGQGRLPFAWSGVSLYASGAAALRVRLAPAGGDGVRLEIADTAGVPVAAVEALRLRPVSAEQVR | ||||||
Domain | 3255-3330 | Carrier | ||||
Sequence: RLLLDLVRAQVATVLGYAGAETIGSARAFKELGFDSLTAVELRNHLNTVTGLRLPATLVFDYPDPTVLARHLRTEL | ||||||
Domain | 3351-3777 | Ketosynthase family 3 (KS3) | ||||
Sequence: DDAIAIVGMSCRYPGGVGTPEELWQLVMGSVDAVSDFPADRGWDLDGLRSDDPGRAGTSTTGQGGFLHDAAEFDPDFFGISPREALAMDPQQRLLLETSWEAFERAGIDPGALRGSRTGVFAGVMYHDYLSRLNAVPEGLEGYLGTGSAGSVASGRVAYTFGLEGPAVTIDTACSSSLVALHLAAQALRNGECSLALAGGVTVMATPETFIDFSRQGGLSTSGRCKSFAASADGTGWAEGAGMLLVERLSDARRNGHRVLAVVRGSAINQDGASNGLTAPNGPSQQRVIREALTSARLTTADVDVVEAHGTGTKLGDPIEAQALLATYGRERPEGQPLWLGSLKSNIGHAQAAAGVAGVIKMIMAMRHGVLPRTLHIDEPTPHVDWAAGDVELLTESRPWPETGRPRRAAVSSFGVSGTNAHTILEQ | ||||||
Region | 3396-3415 | Disordered | ||||
Sequence: DGLRSDDPGRAGTSTTGQGG | ||||||
Domain | 4787-4862 | Carrier | ||||
Sequence: RVLLDLVRSAVADVLGHADAEAVEASRAFSELGFDSLTAVELRNRLNTVTGLRLPPTLVYDYPTSSALAAHLRTEI | ||||||
Domain | 4886-5312 | Ketosynthase family 3 (KS3) | ||||
Sequence: DDPIAIVGMSCRFPGRVDSPEELWRLLSTGQDAVTEFPADRGWDIDSLYDPEPGTEYTTYVREGGFLSDAGDFDAAFFGISPREALAMDPQQRLLLETSWEAFERAGIDPTTLRGQQVGVFAGTNGQDYLSLVLQSQDSGDGFMGTGNAASVLSGRVSYALGLEGPAVTVDTACSSSLVALHWAIQALRAGECSLALAGGVTVMSTPGSFVDFSRQRGLAADGRIKAFAAGADGTGWGEGVGMLLVERLSDARRHGHTVLATVRGSAINQDGASNGLTAPNGPSQQRVIRQALAGAGLSASEVDAVEAHGTGTTLGDPIEAQALLATYGQDRSEGQPLLLGSIKSNIGHTQAAAGVAGVMKMVLALQHGVLPQTLHVDEPTPHVDWSAGELELLTEAREWPETGRPRRAAVSSFGISGTNAHTVLEQ | ||||||
Region | 5779-5904 | N-terminal hotdog fold | ||||
Sequence: HPLLGAAVELPDKDAFLFSGRLALASHSWLADHTVADTAVLPGSAFVELAVRAGDQVGCDRVDELALEEPLILPERGGVQLRVSVGEPDGEGRRPLAVYSRPEGAESDQPWTRHAGGVLGTAEGRA | ||||||
Domain | 5779-6082 | PKS/mFAS DH | ||||
Sequence: HPLLGAAVELPDKDAFLFSGRLALASHSWLADHTVADTAVLPGSAFVELAVRAGDQVGCDRVDELALEEPLILPERGGVQLRVSVGEPDGEGRRPLAVYSRPEGAESDQPWTRHAGGVLGTAEGRAAAEAGAFAVWPPADAEPVDTGALYAGMARAGLLHGPAFQSLRHVWRRGEELYAEVRIGEERQADAARFALHPALLDGALQPLGLGVDGAAVAASWRGLSLYAVGAEALRVRLTPAADGTTRLVAADETGALVASVDALAAEPLDADRIAGASATSGRQDTLFRVDWAPVAATSEAPSA | ||||||
Region | 5919-6082 | C-terminal hotdog fold | ||||
Sequence: AEPVDTGALYAGMARAGLLHGPAFQSLRHVWRRGEELYAEVRIGEERQADAARFALHPALLDGALQPLGLGVDGAAVAASWRGLSLYAVGAEALRVRLTPAADGTTRLVAADETGALVASVDALAAEPLDADRIAGASATSGRQDTLFRVDWAPVAATSEAPSA | ||||||
Domain | 6557-6632 | Carrier | ||||
Sequence: RTVLDLVRRQVAAVLGYASKEQVGAEQAFKELGFDSLTAVELRNRLNAATGLKLTATLVYDYPTPMALARQLRHEM |
Keywords
- Domain