A0A1L7NKL1 · A0A1L7NKL1_PSEPU
- ProteinDNA topoisomerase 4 subunit A
- GeneparC
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids752 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.
Catalytic activity
Features
Showing features for site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Site | 46 | Interaction with DNA | |||
Site | 82 | Interaction with DNA | |||
Site | 84 | Interaction with DNA | |||
Site | 126 | Transition state stabilizer | |||
Active site | 127 | O-(5'-phospho-DNA)-tyrosine intermediate | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Cellular Component | cytoplasm | |
Cellular Component | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex | |
Cellular Component | extrinsic component of plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | DNA binding | |
Molecular Function | DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity | |
Biological Process | chromosome segregation | |
Biological Process | DNA topological change |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDNA topoisomerase 4 subunit A
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas
Accessions
- Primary accessionA0A1L7NKL1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Subunit
Heterotetramer composed of ParC and ParE.
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length752
- Mass (Da)83,071
- Last updated2017-03-15 v1
- ChecksumAB20C5F93860B3CD
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP015029 EMBL· GenBank· DDBJ | BAW25963.1 EMBL· GenBank· DDBJ | Genomic DNA |