A0A1L7NKL1 · A0A1L7NKL1_PSEPU

Function

function

Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.

Catalytic activity

  • ATP-dependent breakage, passage and rejoining of double-stranded DNA.
    EC:5.6.2.2 (UniProtKB | ENZYME | Rhea)

Features

Showing features for site, active site.

1752100200300400500600700
Type
IDPosition(s)Description
Site46Interaction with DNA
Site82Interaction with DNA
Site84Interaction with DNA
Site126Transition state stabilizer
Active site127O-(5'-phospho-DNA)-tyrosine intermediate

GO annotations

AspectTerm
Cellular Componentchromosome
Cellular Componentcytoplasm
Cellular ComponentDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
Cellular Componentextrinsic component of plasma membrane
Molecular FunctionATP binding
Molecular FunctionDNA binding
Molecular FunctionDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
Biological Processchromosome segregation
Biological ProcessDNA topological change

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA topoisomerase 4 subunit A
  • EC number
  • Alternative names
    • Topoisomerase IV subunit A

Gene names

    • Name
      parC
    • ORF names
      KF715C_ch53900

Organism names

Accessions

  • Primary accession
    A0A1L7NKL1

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Heterotetramer composed of ParC and ParE.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-465DNA topoisomerase type IIA

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    752
  • Mass (Da)
    83,071
  • Last updated
    2017-03-15 v1
  • Checksum
    AB20C5F93860B3CD
MSDSLELSLDGVERRSLADFTEQAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELGLDADAKHKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYTLVDGQGNWGAPDDPKSFAAMRYTEARLSRYAEVLLSEVGQGTVDWVPNFDGTLQEPAVLPARLPNILLNGTTGIAVGMATDVPPHNLREVASACVRLLDEPKATIEQLCEHIQGPDYPTEAEIITPRSEILKMYESGRGSIRMRAVYRVEDGDIVVTALPHQVSGAKVLEQIAAQMQAKKLPMVADLRDESDHENPCRIVIIPRSNRVDADELMQHLFATTDLESSYRVNVNIIGLDGRPQLKNLRAILVEWLEFRTNTVRRRLQHRLDKVERRLHLLDGLLTAFLNLDEVIHIIRTEEHPKQALIARFELSEIQAEYILETRLRQLARLEEMKIRGEQDELLKEQAKLQALLGSEAKLRKLVRSELIKDAETYGDARRSPIVERVEAKALSENELMPTEPVTVVLSEKGWVRCAKGHDIDATGLSYKAGDGFKAAAAGRSNQFAVLIDSTGRSYSVAAHSLPSARGQGEPLTGRLTPPPGATFECVLLPDDDALYVVASDAGYGFVVKGEDLQAKNKAGKGLLSLPNGAKVMTPRPVANREQDWLAAVTTEGRLLVFKVSDLPQLGKGKGNKIIGVPGDRVASREEYVTDLAVIAEGATLVLQAGKRTLSLKADDLEHYKGERGRRGSKLPRGFQRVDGLQVEVPA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP015029
EMBL· GenBank· DDBJ
BAW25963.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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