A0A1L7HZL2 · A0A1L7HZL2_9FLAO

Function

function

Bifunctional aspartate kinase and homoserine dehydrogenase that catalyzes the first and the third steps toward the synthesis of lysine, methionine and threonine from aspartate.

Catalytic activity

Cofactor

a metal cation (UniProtKB | Rhea| CHEBI:25213 )

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.
Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.
Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.

GO annotations

AspectTerm
Molecular Functionaspartate kinase activity
Molecular FunctionATP binding
Molecular Functionhomoserine dehydrogenase activity
Molecular FunctionNADP binding
Biological Processhomoserine biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate
Biological Processthreonine biosynthetic process

Keywords

Enzyme and pathway databases

    • UPA00034UER00015
    • UPA00050UER00063
    • UPA00051UER00462

Names & Taxonomy

Protein names

  • Submitted names
    • Aspartokinase
      (EC:1.1.1.3
      , EC:2.7.2.4
      )

Gene names

    • ORF names
      GRFL_0062

Organism names

  • Taxonomic identifier
  • Strain
    • JLT2011
  • Taxonomic lineage
    Bacteria > Bacteroidota > Flavobacteriia > Flavobacteriales > Flavobacteriaceae > Christiangramia

Accessions

  • Primary accession
    A0A1L7HZL2

Proteomes

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

In the C-terminal section; belongs to the homoserine dehydrogenase family.
In the N-terminal section; belongs to the aspartokinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    815
  • Mass (Da)
    90,108
  • Last updated
    2017-03-15 v1
  • Checksum
    125A508297C97DA2
MKVLKFGGSSLASPERIKLVSKTIQKHLEEDAVVSVFSAFGGVTNDLLEMAELAAKEDIRYKEILAANEKRHLDAARELVPVANQSSILSKIKNEFNRLETLYEGVYLLNELSDKTRHVISGFGEILSSQIIAEYFKGLGIKSQFADTRDLIVAKNASEKVQVNYDLTNANIEIFFGSHQSGLYVVPGFVSKNEQGFPSTLGRGGSDFTAAIIAGALHTEKVLIYTDVNGMYTANPNLVPHAYSLKEISYEEAMELSHFGAKVLYPPTIQPLLDKKIEIHIKNTFEPEQAGTVISRSSKKNFRWVTGITHIDSIKLVNIEGSGMVGVPGFSKRLFETLYLEGVNVVLITQASSEHSICIAVKADEAEKAKAAVDEAFQNEIAFKKIKPAEIEGNVAIIALVGDRMKSHHGLSGKMFSALGNNNINIRAIAQGSSERNISAVIAKKDVTKALNTLHEQFFEVPSKEINLFVTGVGNVGGKLIAQLKKQEDYLLEKLRLKIRVLALSNSRQMLFNEDGIDLDNWQEELKNGEPANKQEFLDRVREFNLRNSIFVDNTASADISQYYKHYLADSVSVVTCNKIACADAYENYEQLQNLAREYGASFLYETNVGAGLPIIDTLQNLIASGDRIQKIQAVLSGSLNYVFNTYDTSEPFYKVVEQAKEQGYTEPDPKIDLSGVDVARKILILARESGLKLELDDIERDDFLSQESLHSTSNEEFFELLKKDEPAFQKIYENAKSKGSELKYVAQLENGKAKVGLQEVGPQHPFANLSGSDNIVLFFTDRYPEQPLIVKGAGAGADVTASGIFADIIRIGKK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP016359
EMBL· GenBank· DDBJ
APU66786.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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